Attention-deficithyperactivity disorder (ADHD) is a commonbut controversial syndrome characterized by developmentallyinappropriate hyperactivity, impulsivity, and inattention.1The disorder, which continues throughout life,2,3,4,5,6,7 usuallybegins in childhood and is characterized by excessive activity,even when adjusted for developmental level, and limited behavioralcontrol. A severely affected child, in whom behavioral controlis absent, is exhausting to care for.
ADHD is controversial despite the acceptance of specific diagnosticcriteria. That it is an extreme form of commonly occurring typesof behavior rather than a disorder with discrete determinantsis suggested by genetic studies, including a large study oftwins, in which . . . [Full Text of this Article]
Prevalence
Genetics
Course
Treatment
Stimulant-Drug Preparations
Adverse Effects
Antidepressant Drugs
Alpha-AdrenergicAgonist Drugs
Psychosocial Interventions
Other Treatments
Conclusions
Source Information
From the Department of Child and Adolescent Psychiatry, Children's Hospital of Philadelphia, and the Department of Psychiatry, University of Pennsylvania School of Medicine, Philadelphia (J.E.); the Department of Psychiatry, Division of Child and Adolescent Psychiatry, MCPHahnemann University, Philadelphia (P.J.A.); and the Child Psychiatry Branch, National Institute of Mental Health, Bethesda, Md. (J.L.R.).
Address reprint requests to Dr. Elia at the Children's Hospital of Philadelphia, Main Bldg., Rm. 3636, 34th St. and Civic Center Blvd., Philadelphia, PA 19104-4399.
References
This article has been cited by other articles:
Biederman, J., Melmed, R. D., Patel, A., McBurnett, K., Konow, J., Lyne, A., Scherer, N., for the SPD503 Study Group,
(2008). A Randomized, Double-Blind, Placebo-Controlled Study of Guanfacine Extended Release in Children and Adolescents With Attention-Deficit/Hyperactivity Disorder. Pediatrics
121: e73-e84
[Abstract][Full Text]
Leslie, L. K., Wolraich, M. L.
(2007). ADHD Service Use Patterns in Youth. J Pediatr Psychol
32: 695-710
[Abstract][Full Text]
Nadkarni, S., LaJoie, J., Devinsky, O.
(2005). Current treatments of epilepsy. Neurology
64: S2-S11
[Abstract][Full Text]
Budson, A. E., Price, B. H.
(2005). Memory Dysfunction. NEJM
352: 692-699
[Full Text]
Teo, S. K., Scheffler, M. R., Wu, A., Stirling, D. I., Thomas, S. D., Stypinski, D., Khetani, V. D.
(2004). A Single-Dose, Two-Way Crossover, Bioequivalence Study of Dexmethylphenidate HCl with and without Food in Healthy Subjects. J Clin Pharmacol
44: 173-178
[Abstract][Full Text]
Olfson, M., Gameroff, M. J., Marcus, S. C., Jensen, P. S.
(2003). National Trends in the Treatment of Attention Deficit Hyperactivity Disorder. Am. J. Psychiatry
160: 1071-1077
[Abstract][Full Text]
Miranda, A., Presentacion, M. J., Soriano, M.
(2002). Effectiveness of a School-Based Multicomponent Program for the Treatment of Children with ADHD. J Learn Disabil
35: 547-563
[Abstract]
Guevara, J., Lozano, P., Wickizer, T., Mell, L., Gephart, H.
(2002). Psychotropic Medication Use in a Population of Children Who Have Attention-Deficit/Hyperactivity Disorder. Pediatrics
109: 733-739
[Abstract][Full Text]
Terry, A. V. Jr., Risbrough, V. B., Buccafusco, J. J., Menzaghi, F.
(2002). Effects of ({+/-})-4-{[2-(1-Methyl-2-pyrrolidinyl)ethyl]thio}phenol Hydrochloride (SIB-1553A), a Selective Ligand for Nicotinic Acetylcholine Receptors, in Tests of Visual Attention and Distractibility in Rats and Monkeys. J. Pharmacol. Exp. Ther.
301: 284-292
[Abstract][Full Text]
Guevara, J. P, Stein, M. T
(2001). Evidence based paediatrics: Evidence based management of attention deficit hyperactivity disorder. BMJ
323: 1232-1235
[Full Text]
Schachter, H. M., Pham, B., King, J., Langford, S., Moher, D.
(2001). How efficacious and safe is short-acting methylphenidate for the treatment of attention-deficit disorder in children and adolescents? A meta-analysis. CMAJ
165: 1475-1488
[Abstract][Full Text]
Vitiello, B.
(2001). Methylphenidate in the treatment of children with attention-deficit hyperactivity disorder. CMAJ
165: 1505-1506
[Full Text]
Jankovic, J.
(2001). Tourette's Syndrome. NEJM
345: 1184-1192
[Full Text]
Poulin, C.
(2001). Medical and nonmedical stimulant use among adolescents: from sanctioned to unsanctioned use. CMAJ
165: 1039-1044
[Abstract][Full Text]
Hill, P, Taylor, E
(2001). Current topic: An auditable protocol for treating attention deficit/hyperactivity disorder. Arch. Dis. Child.
84: 404-409
[Abstract][Full Text]
Markowitz, J. S., DeVane, C. L., Boulton, D. W., Nahas, Z., Risch, S. C., Diamond, F., Patrick, K. S.
(2000). Ethylphenidate Formation in Human Subjects after the Administration of a Single Dose of Methylphenidate and Ethanol. Drug Metab. Dispos.
28: 620-624
[Abstract][Full Text]
Ambrosini, P. J.
(2000). A Review of Pharmacotherapy of Major Depression in Children and Adolescents. Psychiatr. Serv.
51: 627-633
[Abstract][Full Text]
Volkow, N. D., Gatley, S. J., Fowler, J. S., Wang, G., Swanson;, J., Gainetdinov, R. R., Wetsel, W. C., Caron;, M. G.
(2000). Serotonin and the Therapeutic Effects of Ritalin. Science
288: 11a-11
[Full Text]
Kent, M. A., Camfield, C. S., Camfield, P. R.
(1999). Double-blind Methylphenidate Trials: Practical, Useful, and Highly Endorsed by Families. Arch Pediatr Adolesc Med
153: 1292-1296
[Abstract][Full Text]
(1999). Genetics and Treatment of Uncomplicated ADHD. JWatch Neurology
1999: 16-16
[Full Text]