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Previous Volume 340:894-895 March 18, 1999 Number 11 Next

	Since this article has no abstract, we have provided an extract of the first 100 words of the full text and any section headings.

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To the Editor: A 1995 study found that treatment with tissue plasminogen activator (t-PA) was efficacious for intravenous thrombolysis if given within three hours after the onset of ischemic stroke.¹ The drug most likely improves the outcome by inducing early reperfusion of ischemic but not infarcted brain tissue.^2,3 The earlier t-PA is given, the better the chance of clinical improvement and a good outcome.⁴ We describe a case in which early intravenous treatment with t-PA, monitored noninvasively by transcranial Doppler ultrasonography, produced dramatic clinical improvement.

While at work, an 85-year-old right-handed woman suddenly became mute and weak on her right . . . [Full Text of this Article]

References

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• Tsivgoulis, G., Alexandrov, A. (2008). Ultrasound-Enhanced Thrombolysis: From Bedside to Bench. Stroke 39: 1404-1405 [Full Text]  
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• Molina, C. A., Montaner, J., Abilleira, S., Arenillas, J. F., Ribo, M., Huertas, R., Romero, F., Alvarez-Sabin, J. (2001). Time Course of Tissue Plasminogen Activator-Induced Recanalization in Acute Cardioembolic Stroke: A Case-Control Study. Stroke 32: 2821-2827 [Abstract] [Full Text]  
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