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Volume 340:967-969 March 25, 1999 Number 12
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Bradykinin and Inhibition of Angiotensin-Converting Enzyme in Hypertension

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 by Gainer, J. V.
To the Editor: Gainer et al. (Oct. 29 issue)1 show that the short-term effects on blood pressure and renin levels of a single oral dose of 25 mg of captopril in sodium-depleted normotensive and hypertensive subjects can be reduced by a simultaneous intravenous infusion of the B2-receptor antagonist icatibant (100 µg per kilogram of body weight).

The authors suggest that the short-term hemodynamic effect of 25 mg of captopril was stronger than that of 75 mg of losartan and that the combination of captopril and icatibant resulted in a reduction in blood pressure that was similar to the reduction . . . [Full Text of this Article]

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