To the Editor: Chemoprevention can prevent second primary cancersin patients with cancer,1 but the effect of secondary cancerprevention on absolute survival has not been established. In1996 we reported in the Journal that oral administration ofan acyclic retinoid for 12 months significantly reduced theincidence of second primary cancers in patients who had receivedcurative treatment for hepatocellular carcinomas,2 but the effecton survival did not reach statistical significance after a medianfollow-up period of 38 months.
We have subsequently reexamined the patients every three months.Patients in whom a second primary hepatocellular carcinoma developedreceived mainly . . . [Full Text of this Article]
References
This article has been cited by other articles:
Shimizu, M., Fukutomi, Y., Ninomiya, M., Nagura, K., Kato, T., Araki, H., Suganuma, M., Fujiki, H., Moriwaki, H.
(2008). Green Tea Extracts for the Prevention of Metachronous Colorectal Adenomas: A Pilot Study. Cancer Epidemiol. Biomarkers Prev.
17: 3020-3025
[Abstract][Full Text]
Yamazaki, K., Shimizu, M., Okuno, M., Matsushima-Nishiwaki, R., Kanemura, N., Araki, H., Tsurumi, H., Kojima, S., Weinstein, I B., Moriwaki, H.
(2007). Synergistic effects of RXR{alpha} and PPAR{gamma} ligands to inhibit growth in human colon cancer cells phosphorylated RXR{alpha} is a critical target for colon cancer management. Gut
56: 1557-1563
[Abstract][Full Text]
Yuan, J.-M., Gao, Y.-T., Ong, C.-N., Ross, R. K., Yu, M. C.
(2006). Prediagnostic level of serum retinol in relation to reduced risk of hepatocellular carcinoma.. JNCI J Natl Cancer Inst
98: 482-490
[Abstract][Full Text]
Okudaira, T., Tomita, M., Uchihara, J.-N., Matsuda, T., Ishikawa, C., Kawakami, H., Masuda, M., Tanaka, Y., Ohshiro, K., Takasu, N., Mori, N.
(2006). NIK-333 inhibits growth of human T-cell leukemia virus type I-infected T-cell lines and adult T-cell leukemia cells in association with blockade of nuclear factor-{kappa}B signal pathway.. Molecular Cancer Therapeutics
5: 704-712
[Abstract][Full Text]
de Almeida Vasconcelos Fonseca, E. M., Chagas, C. E. A., Mazzantini, R. P., Heidor, R., Ong, T. P., Moreno, F. S.
(2005). All-trans and 9-cis retinoic acids, retinol and {beta}-carotene chemopreventive activities during the initial phases of hepatocarcinogenesis involve distinct actions on glutathione S-transferase positive preneoplastic lesions remodeling and DNA damage. Carcinogenesis
26: 1940-1946
[Abstract][Full Text]
Tanabe, K. K., Blaszkowsky, L. S., Chung, R. T., Blake, M. A., Lauwers, G. Y.
(2005). Case 23-2005 - A 57-Year-Old Man with a Mass in the Liver. NEJM
353: 401-410
[Full Text]
de Moura Espindola, R., Mazzantini, R. P., Ong, T. P., de Conti, A., Heidor, R., Moreno, F. S.
(2005). Geranylgeraniol and {beta}-ionone inhibit hepatic preneoplastic lesions, cell proliferation, total plasma cholesterol and DNA damage during the initial phases of hepatocarcinogenesis, but only the former inhibits NF-{kappa}B activation. Carcinogenesis
26: 1091-1099
[Abstract][Full Text]
Shimizu, M., Suzui, M., Deguchi, A., Lim, J. T. E., Xiao, D., Hayes, J. H., Papadopoulos, K. P., Weinstein, I. B.
(2004). Synergistic Effects of Acyclic Retinoid and OSI-461 on Growth Inhibition and Gene Expression in Human Hepatoma Cells. Clin. Cancer Res.
10: 6710-6721
[Abstract][Full Text]
Shidoji, Y., Ogawa, H.
(2004). Natural occurrence of cancer-preventive geranylgeranoic acid in medicinal herbs. J. Lipid Res.
45: 1092-1103
[Abstract][Full Text]
Suzui, M., Shimizu, M., Masuda, M., Lim, J. T. E., Yoshimi, N., Weinstein, I. B.
(2004). Acyclic retinoid activates retinoic acid receptor {beta} and induces transcriptional activation of p21CIP1 in HepG2 human hepatoma cells. Molecular Cancer Therapeutics
3: 309-316
[Abstract][Full Text]
Shimizu, M., Suzui, M., Deguchi, A., Lim, J. T. E., Weinstein, I. B.
(2004). Effects of Acyclic Retinoid on Growth, Cell Cycle Control, Epidermal Growth Factor Receptor Signaling, and Gene Expression in Human Squamous Cell Carcinoma Cells. Clin. Cancer Res.
10: 1130-1140
[Abstract][Full Text]
Sano, K., Takayama, T., Murakami, K., Saiki, I., Makuuchi, M.
(2003). Overexpression of Retinoic Acid Receptor {alpha} in Hepatocellular Carcinoma. Clin. Cancer Res.
9: 3679-3683
[Abstract][Full Text]
Matsushima-Nishiwaki, R., Okuno, M., Takano, Y., Kojima, S., Friedman, S. L., Moriwaki, H.
(2003). Molecular mechanism for growth suppression of human hepatocellular carcinoma cells by acyclic retinoid. Carcinogenesis
24: 1353-1359
[Abstract][Full Text]
Ryder, S D
(2003). Guidelines for the diagnosis and treatment of hepatocellular carcinoma (HCC) in adults. Gut
52: iii1-8
[Full Text]
Wang, X.-D.
(2003). Retinoids and Alcohol-Related Carcinogenesis. J. Nutr.
133: 287S-290
[Abstract][Full Text]
Suzui, M., Masuda, M., Lim, J. T. E., Albanese, C., Pestell, R. G., Weinstein, I. B.
(2002). Growth Inhibition of Human Hepatoma Cells by Acyclic Retinoid Is Associated with Induction of p21CIP1 and Inhibition of Expression of Cyclin D1. Cancer Res.
62: 3997-4006
[Abstract][Full Text]
Matsushima-Nishiwaki, R., Okuno, M., Adachi, S., Sano, T., Akita, K., Moriwaki, H., Friedman, S. L., Kojima, S.
(2001). Phosphorylation of Retinoid X Receptor {alpha} at Serine 260 Impairs Its Metabolism and Function in Human Hepatocellular Carcinoma. Cancer Res.
61: 7675-7682
[Abstract][Full Text]
Okada, S.
(2001). Cancer Chemoprevention as Adjuvant Therapy for Hepatocellular Carcinoma. Jpn J Clin Oncol
31: 357-358
[Full Text]
Okuno, M., Sano, T., Matsushima-Nishiwaki, R., Adachi, S., Akita, K., Okano, Y., Kojima, S., Moriwaki, H.
(2001). Apoptosis Induction by Acyclic Retinoid: a Molecular Basis of 'Clonal Deletion' Therapy for Hepatocellular Carcinoma. Jpn J Clin Oncol
31: 359-362
[Abstract][Full Text]
Chung, J., Liu, C., Smith, D. E., Seitz, H. K., Russell, R. M., Wang, X.-D.
(2001). Restoration of retinoic acid concentration supresses ethanol-enhanced c-Jun expression and hepatocyte proliferation in rat liver. Carcinogenesis
22: 1213-1219
[Abstract][Full Text]
Previous
