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Previous Volume 340:1121-1122 April 8, 1999 Number 14 Next

	Since this article has no abstract, we have provided an extract of the first 100 words of the full text and any section headings.

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To the Editor: Congenital adrenal hyperplasia due to 21-hydroxylase deficiency results in deficient production of cortisol and aldosterone, chronic stimulation of the adrenal cortex by corticotropin, and overproduction of androgens. Cortisol-replacement therapy often fails to normalize corticotropin and androgen secretion, and high doses may be needed.¹ Adrenocortical tumors, including cancers, are rare in patients with 21-hydroxylase deficiency but have been reported in patients with large adrenal glands and presumably inadequate cortisol therapy.²

A 16-year-old girl with 21-hydroxylase deficiency was evaluated for hirsutism and primary amenorrhea. She had a muscular habitus, hyperpigmentation, and a low voice. Physical examination revealed a beard, . . . [Full Text of this Article]

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