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Previous Volume 340:1280-1282 April 22, 1999 Number 16 Next

	Since this article has no abstract, we have provided an extract of the first 100 words of the full text and any section headings.

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Nearly a century after Reed–Sternberg cells in Hodgkin's disease were first described, information about these unusual cells has begun to accumulate rapidly. Cytogenetic studies have clearly demonstrated that, in a given case, these cells arise from a single clone.^1,2,3 Even so, the progenitor of this clone has for years eluded detection. In this issue of the Journal, Bräuninger and colleagues⁴ report their studies of two patients in whom both a B-cell lymphoma and Hodgkin's disease developed. From their molecular investigations of these rare "double" lymphomas, they conclude that a common B-cell precursor located in a germinal center gave rise to . . . [Full Text of this Article]

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