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Correspondence
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Volume 340:1288 April 22, 1999 Number 16
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Deafness and Mutations in the Connexin 26 Gene

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To the Editor: Morell et al. (Nov. 19 issue)1 demonstrate that two mutations in the connexin 26 gene (GJB2) account for most of the cases of nonsyndromic recessive deafness among Ashkenazi Jews. They suggested that since the carrier rate of mutations in the GJB2 gene (4.76 percent) is similar to that of other genes governing recessive diseases in this population, such as Tay–Sachs disease, Gaucher's disease, and familial dysautonomia, Ashkenazi Jews may elect to have their carrier status determined as part of genetic screening.

Although the frequency of a disease within a population is an important factor in . . . [Full Text of this Article]

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