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Correction to Ernst and Zibrak, N Engl J Med 339(22):1603-1608 November 26, 1998.

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Volume 340:1290-1292 April 22, 1999 Number 16
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Carbon Monoxide Poisoning

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 by Ernst, A.
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 by Ernst, A.
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To the Editor: Ernst and Zibrak (Nov. 26 issue)1 state that coma is an undisputed indication for hyperbaric-oxygen therapy, but this claim has not been proved2 and might be misleading. Neurocognitive sequelae can develop in comatose patients with carbon monoxide poisoning who are treated with hyperbaric oxygen,3 and patients with severe carbon monoxide poisoning can have a normal functional and cognitive recovery without hyperbaric oxygen.4

Interim analysis of an ongoing randomized clinical trial5 and one completed randomized clinical trial6 of the role of hyperbaric oxygen therapy in acute carbon monoxide poisoning have failed to demonstrate differences in outcomes between patients . . . [Full Text of this Article]

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