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Correspondence
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Volume 340:1369-1370 April 29, 1999 Number 17
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The Effect of Tolerance to Noninherited Maternal HLA Antigens on the Survival of Renal Transplants from Sibling Donors

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 by Burlingham, W. J.
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To the Editor: Burlingham et al. (Dec. 3 issue)1 provide evidence that the survival rate of kidney grafts from sibling donors with a mismatch of one HLA haplotype was significantly higher if the mismatched haplotype was derived from the mother rather than the father. This finding has important immunologic and clinical implications.

My colleagues and I attempted to verify the results in an analysis of transplantations reported to the Collaborative Transplant Study by 49 transplantation centers in 22 countries. We were able to analyze 264 transplantations performed between 1985 and 1997. The survival rate of 122 transplants from sibling donors . . . [Full Text of this Article]

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