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Although Jenner first used his smallpox vaccine more than 200 years ago, not until the latter half of this century did the "age of immunizations" begin. No other technological innovation has come close to yielding the public health benefits that are provided by vaccines, nearly all of which have become available within the past 50 years. Frighteningly palpable during the first half of the century, scourges like poliomyelitis, diphtheria, measles, pertussis, and mumps, with their unavoidable epidemics and frequently disabling sequelae, are now almost unknown in countries able to muster and sustain effective immunization-delivery programs. The most recent and dramatic
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