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Correspondence
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Volume 340:1443-1444 May 6, 1999 Number 18
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Carvedilol

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 by Frishman, W. H.
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To the Editor: In his review of carvedilol, Frishman (Dec. 10 issue)1 did not adequately distinguish the effects of the drug in patients with dilated cardiomyopathy from those in patients with ischemic cardiomyopathy. Bristow et al.2 have shown that there are differences between these two disorders in ß-adrenergic activation. The Australia–New Zealand Heart Failure Research Collaborative Group3,4 has assessed the efficacy of carvedilol in patients with ischemic cardiomyopathy. The investigators reported an increase in symptoms of congestive heart failure with carvedilol as compared with placebo. Carvedilol did result in an increase in left ventricular ejection fraction and a decrease in . . . [Full Text of this Article]

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