FREE NEJM E-TOC    HOME   |   SUBSCRIBE   |   CURRENT ISSUE   |   PAST ISSUES   |   COLLECTIONS   |   Search Term  Advanced Search

Sign in | Get NEJM's E-Mail Table of Contents — Free | Subscribe

Previous Volume 340:1476-1480 May 13, 1999 Number 19 Next

	Since this article has no abstract, we have provided an extract of the first 100 words of the full text and any section headings.

	Full Text PDF Editorial by Yudofsky, S. C. Letters Add to Personal Archive Add to Citation Manager Notify a Friend E-mail When Cited PubMed Citation

Continuous high-frequency stimulation of the basal ganglia was recently introduced for the treatment of patients with advanced Parkinson's disease.¹ This treatment seems to be most effective when the electrodes are placed in the subthalamic nuclei.^2,3 Among the 20 patients treated successfully by bilateral subthalamic stimulation at our center, 1 woman had transient acute depression when high-frequency stimulation was delivered to the left substantia nigra, 2 mm below the site where stimulation alleviated the signs of Parkinson's disease. We describe here the results of detailed studies of the induction of major, reversible depression in this woman.

Case Report

A 65-year-old right-handed woman with . . . [Full Text of this Article]

Results

Discussion

Source Information

From the Centre d'Investigation Clinique, Fédération de Neurologie and INSERM Unité 289 (B.-P.B., P.D., I.A., A.-M.B., Y.A.), Service de Neuroradiologie (D.D.), Service de Neurochirurgie (P.C.), and Service d'Explorations Fonctionnelles Neurologiques (B.P.), Groupe Hospitalier Pitié–Salpêtrière, Paris; and the Service Hospitalier Frederic Joliot, Commissariat à l'Energie Atomique, Orsay, France (L.T., Y.S.).

Address reprint requests to Dr. Bejjani at the Centre d'Investigation Clinique, Hôpital Pitié–Salpêtrière, 47 Blvd. de l'Hôpital, 75651 Paris CEDEX 13, France, or at cic.salpetriere@psl.ap-hop-paris.fr.

References

Related Letters:

Transient Acute Depression Induced by High-Frequency Deep-Brain Stimulation
Bezerra M. L.S., Martínez J.-V. L., Nasser J. A., Kumar R., Krack P., Pollak P., Landau W. M., Perlmutter J. S., Bejjani B.-P., Damier P., Agid Y.
Extract | Full Text  
N Engl J Med 1999; 341:1003-1004, Sep 23, 1999. Correspondence

This article has been cited by other articles:

• Temel, Y., Tan, S., Visser-Vandewalle, V., Sharp, T. (2009). Parkinson's disease, DBS and suicide: a role for serotonin?. Brain 0: awp150v1-awp150 [Full Text]  
• Tye, S. J., Frye, M. A., Lee, K. H. (2009). Disrupting Disordered Neurocircuitry: Treating Refractory Psychiatric Illness With Neuromodulation. Mayo Clin Proc. 84: 522-532 [Abstract] [Full Text]  
• Olanow, C. W., Stern, M. B., Sethi, K. (2009). The scientific and clinical basis for the treatment of Parkinson disease (2009). Neurology 72: S1-S136 [Abstract] [Full Text]  
• Parvizi, J., Coburn, K. L., Shillcutt, S. D., Coffey, C. E., Lauterbach, E. C., Mendez, M. F. (2009). Neuroanatomy of Pathological Laughing and Crying: A Report of the American Neuropsychiatric Association Committee on Research. J. Neuropsychiatry Clin. Neurosi. 21: 75-87 [Abstract] [Full Text]  
• Chastan, N., Westby, G. W. M., Yelnik, J., Bardinet, E., Do, M. C., Agid, Y., Welter, M. L. (2009). Effects of nigral stimulation on locomotion and postural stability in patients with Parkinson's disease. Brain 132: 172-184 [Abstract] [Full Text]  
• Soulas, T, Gurruchaga, J-M, Palfi, S, Cesaro, P, Nguyen, J-P, Fenelon, G (2008). Attempted and completed suicides after subthalamic nucleus stimulation for Parkinson's disease. J. Neurol. Neurosurg. Psychiatry 79: 952-954 [Abstract] [Full Text]  
• Mathews, D.J.H., Sugarman, J., Bok, H., Blass, D. M., Coyle, J. T., Duggan, P., Finkel, J., Greely, H. T., Hillis, A., Hoke, A., Johnson, R., Johnston, M., Kahn, J., Kerr, D., Kurtzberg, J., Liao, S. M., McDonald, J. W., McKhann, G., Nelson, K. B., Rao, M., Regenberg, A., Siegel, A. W., Smith, K., Solter, D., Song, H., Vescovi, A., Young, W., Gearhart, J. D., Faden, R. (2008). Cell-based interventions for neurologic conditions: Ethical challenges for early human trials. Neurology 71: 288-293 [Abstract] [Full Text]  
• Neimat, J. S., Hamani, C., Giacobbe, P., Merskey, H., Kennedy, S. H., Mayberg, H. S., Lozano, A. M. (2008). Neural Stimulation Successfully Treats Depression in Patients With Prior Ablative Cingulotomy. Am. J. Psychiatry 165: 687-693 [Full Text]  
• Low, H. L., Sayer, F. T., Honey, C. R. (2008). Pathological Crying Caused by High-Frequency Stimulation in the Region of the Caudal Internal Capsule. Arch Neurol 65: 264-266 [Abstract] [Full Text]  
• Temel, Y., Boothman, L. J., Blokland, A., Magill, P. J., Steinbusch, H. W. M., Visser-Vandewalle, V., Sharp, T. (2007). Inhibition of 5-HT neuron activity and induction of depressive-like behavior by high-frequency stimulation of the subthalamic nucleus. Proc. Natl. Acad. Sci. USA 104: 17087-17092 [Abstract] [Full Text]  
• Okun, M. S, Mann, G., Foote, K. D, Shapira, N. A, Bowers, D., Springer, U., Knight, W., Martin, P., Goodman, W. K (2007). Deep brain stimulation in the internal capsule and nucleus accumbens region: responses observed during active and sham programming. J. Neurol. Neurosurg. Psychiatry 78: 310-314 [Abstract] [Full Text]  
• Dunlop, B. W., Nemeroff, C. B. (2007). The Role of Dopamine in the Pathophysiology of Depression. Arch Gen Psychiatry 64: 327-337 [Full Text]  
• TAKANO, H., MOTOHASHI, N., UEMA, T., OGAWA, K., OHNISHI, T., NISHIKAWA, M., KASHIMA, H., MATSUDA, H. (2007). Changes in regional cerebral blood flow during acute electroconvulsive therapy in patients with depression: Positron emission tomographic study. Br. J. Psychiatry 190: 63-68 [Abstract] [Full Text]  
• Ulla, M, Thobois, S, Lemaire, J-J, Schmitt, A, Derost, P, Broussolle, E, Llorca, P-M, Durif, F (2006). Manic behaviour induced by deep-brain stimulation in Parkinson's disease: evidence of substantia nigra implication?. J. Neurol. Neurosurg. Psychiatry 77: 1363-1366 [Abstract] [Full Text]  
• Smeding, H.M.M., Speelman, J. D., Koning-Haanstra, M., Schuurman, P. R., Nijssen, P., van Laar, T., Schmand, B. (2006). Neuropsychological effects of bilateral STN stimulation in Parkinson disease: A controlled study. Neurology 66: 1830-1836 [Abstract] [Full Text]  
• Kuhn, A. A., Hariz, M. I., Silberstein, P., Tisch, S., Kupsch, A., Schneider, G. -H., Limousin-Dowsey, P., Yarrow, K., Brown, P. (2005). Activation of the subthalamic region during emotional processing in Parkinson disease. Neurology 65: 707-713 [Abstract] [Full Text]  
• Czernecki, V, Pillon, B, Houeto, J L, Welter, M L, Mesnage, V, Agid, Y, Dubois, B (2005). Does bilateral stimulation of the subthalamic nucleus aggravate apathy in Parkinson's disease?. J. Neurol. Neurosurg. Psychiatry 76: 775-779 [Abstract] [Full Text]  
• Leentjens, A. F. G. (2004). Depression in Parkinson's Disease: Conceptual Issues and Clinical Challenges. J Geriatr Psychiatry Neurol 17: 120-126 [Abstract]  
• Burn, D. J., Troster, A. I. (2004). Neuropsychiatric Complications of Medical and Surgical Therapies for Parkinson's Disease. J Geriatr Psychiatry Neurol 17: 172-180 [Abstract]  
• Richard, I. H., McDonald, W. M. (2004). Can "blue" genes affect mood and movement?. Neurology 63: 610-611 [Full Text]  
• Okun, M S, Raju, D V, Walter, B L, Juncos, J L, DeLong, M R, Heilman, K, McDonald, W M, Vitek, J L (2004). Pseudobulbar crying induced by stimulation in the region of the subthalamic nucleus. J. Neurol. Neurosurg. Psychiatry 75: 921-923 [Abstract] [Full Text]  
• Christmas, D., Morrison, C., Eljamel, M. S., Matthews, K. (2004). Neurosurgery for mental disorder. Adv. Psychiatr. Treat. 10: 189-199 [Abstract] [Full Text]  
• Dujardin, K, Blairy, S, Defebvre, L, Krystkowiak, P, Hess, U, Blond, S, Destee, A (2004). Subthalamic nucleus stimulation induces deficits in decoding emotional facial expressions in Parkinson's disease. J. Neurol. Neurosurg. Psychiatry 75: 202-208 [Abstract] [Full Text]  
• Okun, M S, Green, J, Saben, R, Gross, R, Foote, K D, Vitek, J L (2003). Mood changes with deep brain stimulation of STN and GPi: results of a pilot study. J. Neurol. Neurosurg. Psychiatry 74: 1584-1586 [Abstract] [Full Text]  
• Narushima, K., Kosier, J. T., Robinson, R. G. (2003). A Reappraisal of Poststroke Depression, Intra- and Inter-Hemispheric Lesion Location Using Meta-Analysis. J. Neuropsychiatry Clin. Neurosi. 15: 422-430 [Abstract] [Full Text]  
• Olanow, C. W. (2003). Present and future directions in the management of motor complications in patients with advanced PD. Neurology 61: S24-33 [Full Text]  
• Fields, J A, Troster, A I, Woods, S P, Higginson, C I, Wilkinson, S B, Lyons, K E, Koller, W C, Pahwa, R (2003). Neuropsychological and quality of life outcomes 12 months after unilateral thalamic stimulation for essential tremor. J. Neurol. Neurosurg. Psychiatry 74: 305-311 [Abstract] [Full Text]  
• Schneider, F., Habel, U., Volkmann, J., Regel, S., Kornischka, J., Sturm, V., Freund, H.-J. (2003). Deep Brain Stimulation of the Subthalamic Nucleus Enhances Emotional Processing in Parkinson Disease. Arch Gen Psychiatry 60: 296-302 [Abstract] [Full Text]  
• Daniele, A, Albanese, A, Contarino, M F, Zinzi, P, Barbier, A, Gasparini, F, Romito, L M A, Bentivoglio, A R, Scerrati, M (2003). Cognitive and behavioural effects of chronic stimulation of the subthalamic nucleus in patients with Parkinson's disease. J. Neurol. Neurosurg. Psychiatry 74: 175-182 [Abstract] [Full Text]  
• Kulisevsky, J., Berthier, M. L., Gironell, A., Pascual-Sedano, B., Molet, J., Pares, P. (2002). Mania following deep brain stimulation for Parkinson's disease. Neurology 59: 1421-1424 [Abstract] [Full Text]  
• Bejjani, B.P., Houeto, J.L., Hariz, M., Yelnik, J., Mesnage, V., Bonnet, A.M., Pidoux, B., Dormont, D., Cornu, P., Agid, Y. (2002). Aggressive behavior induced by intraoperative stimulation in the triangle of Sano. Neurology 59: 1425-1427 [Abstract] [Full Text]  
• Houeto, J L, Mesnage, V, Mallet, L, Pillon, B, Gargiulo, M, du Moncel, S T., Bonnet, A M, Pidoux, B, Dormont, D, Cornu, P, Agid, Y (2002). Behavioural disorders, Parkinson's disease and subthalamic stimulation. J. Neurol. Neurosurg. Psychiatry 72: 701-707 [Abstract] [Full Text]  
• Perlmutter, J. S., Mink, J. W., Bastian, A. J., Zackowski, K., Hershey, T., Miyawaki, E., Koller, W., Videen, T. O. (2002). Blood flow responses to deep brain stimulation of thalamus. Neurology 58: 1388-1394 [Abstract] [Full Text]  
• Adolphs, R. (2002). Recognizing emotion from facial expressions: psychological and neurological mechanisms.. Behav Cogn Neurosci Rev 1: 21-62 [Abstract]  
• Brown, L. L., Feldman, S. M., Smith, D. M., Cavanaugh, J. R., Ackermann, R. F., Graybiel, A. M. (2002). Differential Metabolic Activity in the Striosome and Matrix Compartments of the Rat Striatum during Natural Behaviors. J. Neurosci. 22: 305-314 [Abstract] [Full Text]  
• Olanow, C. W., Watts, R. L., Koller, W. C. (2001). An algorithm (decision tree) for the management of Parkinson's disease (2001):: Treatment. Neurology 56: S1-S88 [Full Text]  
• Molinuevo, J. L., Valldeoriola, F., Tolosa, E., Rumia, J., Valls-Sole, J., Roldan, H., Ferrer, E. (2000). Levodopa Withdrawal After Bilateral Subthalamic Nucleus Stimulation in Advanced Parkinson Disease. Arch Neurol 57: 983-988 [Abstract] [Full Text]  
• Allain, H., Schuck, S., Mauduit, N. (2000). Depression in Parkinson's disease. BMJ 320: 1287-1288 [Full Text]  
• Fins, J. J., Schiff, N. D., Ragnarsson, K. T. (2000). Diagnosis and Treatment of Traumatic Brain Injury. JAMA 283: 2392-2392 [Full Text]  
• Houeto, J. L., Damier, P., Bejjani, P. B., Staedler, C., Bonnet, A. M., Arnulf, I., Pidoux, B., Dormont, D., Cornu, P., Agid, Y. (2000). Subthalamic Stimulation in Parkinson Disease: A Multidisciplinary Approach. Arch Neurol 57: 461-465 [Abstract] [Full Text]  
• Robinson, R. G., Chemerinski, E., Jorge, R. (1999). Pathophysiology of Secondary Depressions in the Elderly. J Geriatr Psychiatry Neurol 12: 128-136 [Abstract]  
• Boylan, L. S., Mann, S. J. (1999). Mutual Influences Between Paroxysmal Hypertension and Psychiatric Disturbance. Arch Intern Med 159: 2091-2092 [Full Text]  
• Bezerra, M. L.S., Martinez, J.-V. L., Nasser, J. A., Kumar, R., Krack, P., Pollak, P., Landau, W. M., Perlmutter, J. S., Bejjani, B.-P., Damier, P., Agid, Y. (1999). Transient Acute Depression Induced by High-Frequency Deep-Brain Stimulation. NEJM 341: 1003-1004 [Full Text]  
• Yudofsky, S. C. (1999). Parkinson's Disease, Depression, and Electrical Stimulation of the Brain. NEJM 340: 1500-1502 [Full Text]