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Previous Volume 340:1476-1480 May 13, 1999 Number 19 Next

	Since this article has no abstract, we have provided an extract of the first 100 words of the full text and any section headings.

	Full Text PDF Editorial by Yudofsky, S. C. Letters Add to Personal Archive Add to Citation Manager Notify a Friend E-mail When Cited PubMed Citation

Continuous high-frequency stimulation of the basal ganglia was recently introduced for the treatment of patients with advanced Parkinson's disease.¹ This treatment seems to be most effective when the electrodes are placed in the subthalamic nuclei.^2,3 Among the 20 patients treated successfully by bilateral subthalamic stimulation at our center, 1 woman had transient acute depression when high-frequency stimulation was delivered to the left substantia nigra, 2 mm below the site where stimulation alleviated the signs of Parkinson's disease. We describe here the results of detailed studies of the induction of major, reversible depression in this woman.

Case Report

A 65-year-old right-handed woman with . . . [Full Text of this Article]

Results

Discussion

Source Information

From the Centre d'Investigation Clinique, Fédération de Neurologie and INSERM Unité 289 (B.-P.B., P.D., I.A., A.-M.B., Y.A.), Service de Neuroradiologie (D.D.), Service de Neurochirurgie (P.C.), and Service d'Explorations Fonctionnelles Neurologiques (B.P.), Groupe Hospitalier Pitié–Salpêtrière, Paris; and the Service Hospitalier Frederic Joliot, Commissariat à l'Energie Atomique, Orsay, France (L.T., Y.S.).

Address reprint requests to Dr. Bejjani at the Centre d'Investigation Clinique, Hôpital Pitié–Salpêtrière, 47 Blvd. de l'Hôpital, 75651 Paris CEDEX 13, France, or at cic.salpetriere@psl.ap-hop-paris.fr.

References

Related Letters:

Transient Acute Depression Induced by High-Frequency Deep-Brain Stimulation
Bezerra M. L.S., Martínez J.-V. L., Nasser J. A., Kumar R., Krack P., Pollak P., Landau W. M., Perlmutter J. S., Bejjani B.-P., Damier P., Agid Y.
Extract | Full Text  
N Engl J Med 1999; 341:1003-1004, Sep 23, 1999. Correspondence

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