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Correspondence
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Volume 340:154 January 14, 1999 Number 2
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Myocardial Infarction during Nifedipine Therapy for Preterm Labor

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To the Editor: Recent studies have suggested that nifedipine is a safer, more effective treatment for preterm labor than the sympathomimetic agents routinely in use.1,2 On the basis of these promising results, calcium-channel antagonists are increasingly prescribed for tocolysis. On the other hand, a case–control study of hypertensive patients found that patients who were taking calcium-channel antagonists had an increased risk of myocardial infarction,3 and a meta-analysis found a dose-dependent association between the use of nifedipine and the risk of death.4 These data, however, are not necessarily applicable to pregnant women who are being treated for preterm labor. We describe . . . [Full Text of this Article]

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