Edited by Josy Reiffers, John M. Goldman, and James O. Armitage. 276 pp. St. Louis, Mosby, 1998. $120. ISBN 1-85317-291-X. (Advances in Blood Disorders. Vol. 2.) Edited by Angelo M. Carella. 453 pp. Amsterdam, Harwood Academic, 1997. $120. ISBN 0-3-7186-5933-6.
In 1957, E. Donnall Thomas, who later won the Nobel prize, reportedon the first attempts to use hematopoietic stem cells as rescuetherapy for patients with leukemia who had received high-dosemyelotoxic treatment. The source was bone marrow. Although Goodmanand colleagues demonstrated in 1962 that pooled blood from donormice successfully restored hematopoiesis in inbred mice thathad received supralethal doses of radiation, there was not muchthought among clinicians at that time of using peripheral bloodin clinical transplantation. The assumption was that there weretoo few stem cells in peripheral blood to ensure successfulengraftment. No . . . [Full Text of this Article]
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