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As the population ages and deaths from preventable causes decline, prostate cancer will more commonly appear on medical-chart "problem lists" and in the absence of effective therapy on death certificates. Three facts emphasize the importance of understanding the biology, diagnosis, and treatment of prostate cancer. In the United States, a man has a one-in-five chance that invasive prostate cancer will develop during his lifetime. His chances that prostate cancer will be diagnosed are nearly twice that of lung cancer and three times that of colorectal cancer. The number of deaths due to prostate cancer, although they represent only
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