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Correspondence
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Volume 340:1685-1687 May 27, 1999 Number 21
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Treatment of Esophageal Cancer

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 by Kelsen, D. P.
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To the Editor: The negative result obtained by Kelsen et al. in their trial of preoperative chemotherapy for operable esophageal cancer (Dec. 31 issue)1 is somewhat surprising, since Herskovic et al.2 reported positive results for similar chemotherapy with or without radiation therapy. Patient accrual in the study by Kelsen et al. was meager (average, <1 patient per hospital per year). How did the study centers maintain high clinical quality, given the low accrual rate? Were there any differences between the centers that were major contributors of data and the rest of the hospitals? Our own results lead us to believe . . . [Full Text of this Article]

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