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Previous Volume 340:1912-1913 June 17, 1999 Number 24 Next

	Since this article has no abstract, we have provided an extract of the first 100 words of the full text and any section headings.

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The discovery of the relation between Kaposi's sarcoma and human herpesvirus 8 (HHV-8, or Kaposi's sarcoma–associated herpesvirus) is a superb example of the benefits gained from the synergy between epidemiologic and laboratory science. A series of epidemiologic observations suggested that Kaposi's sarcoma, the most common AIDS-related cancer, had an infectious cause.¹ Following this lead, Chang et al. used newly developed molecular methods to detect genetic sequences of herpesvirus in Kaposi's sarcoma tissue from patients with AIDS.² Subsequent studies established the presence of HHV-8 DNA in material from lesions obtained from persons with other forms of Kaposi's sarcoma (the "classic" form . . . [Full Text of this Article]

References

This article has been cited by other articles:

• Tedeschi, R., Enbom, M., Bidoli, E., Linde, A., De Paoli, P., Dillner, J. (2001). Viral Load of Human Herpesvirus 8 in Peripheral Blood of Human Immunodeficiency Virus-Infected Patients with Kaposi's Sarcoma. J. Clin. Microbiol. 39: 4269-4273 [Abstract] [Full Text]  
• Campbell, T. B., Borok, M., Gwanzura, L., Bourboulia, D., Boshoff, C., Sitas, F. (1999). HHV-8 Peripheral-Blood Viral Load and the Titer of Antibodies against HHV-8. NEJM 341: 1241-1242 [Full Text]  
• Beral, V., Newton, R., Sitas, F. (1999). Human Herpesvirus 8 and Cancer. JNCI J Natl Cancer Inst 91: 1440-1441 [Full Text]