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Volume 340:2000-2001 June 24, 1999 Number 25
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Etanercept in Rheumatoid Arthritis

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by Tugwell, P.
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by Weinblatt, M. E.
To the Editor: The study by Weinblatt et al. (Jan. 28 issue)1 attempts to demonstrate the efficacy of combined therapy with methotrexate and etanercept through a randomized, double-blind trial. This study design is powerful, but a prerequisite is that the patients assigned to treatment and those assigned to placebo must have equal probabilities of achieving the primary end point — in this case, the American College of Rheumatology criteria for a 20 percent improvement in measures of disease activity.

Weinblatt et al. do not report the functional class of the patients, as defined by the American College of Rheumatology, in . . . [Full Text of this Article]

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