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Previous Volume 340:278-284 January 28, 1999 Number 4 Next

	Since this article has no abstract, we have provided an extract of the first 100 words of the full text and any section headings.

	Full Text PDF Editorial by Raulet, D. H. Letters Add to Personal Archive Add to Citation Manager Notify a Friend E-mail When Cited PubMed Citation

Killer-cell inhibitory receptors inhibit cytolysis when natural killer cells encounter cells bearing HLA class I molecules.^1,2 This phenomenon explains the preferential killing by natural killer cells of tumor cells with reduced expression of HLA class I molecules.³ This finding is the basis of the "missing self" model, in which the HLA class I allele lost by the tumor cells is not available to inhibit the killer cell's lytic machinery.

Different types of killer-cell inhibitory receptors have distinct specificity for HLA-A, B, C, and E antigens.^1,4 In addition, some natural killer cells also possess receptors that induce lysis of cells expressing . . . [Full Text of this Article]

Case Report

Methods

Analysis of Surface Phenotype and Monoclonal Antibodies

Molecular Analysis of Clonality

Purification of CD34+ Cells and Erythroid Progenitors

Assays of Cytotoxic Activity

Results

Discussion

Source Information

From the Departments of Pediatrics (R.H., A.G., R.G., O.T.), Immunology (A.M., P.F.), and Medicine II (W.B., L.K.), University of Tübingen, Tübingen, Germany.

Address reprint requests to Dr. Handgretinger at Children's University Hospital, Hoppe-Seyler-Str. 1, 72076 Tübingen, Germany, or at kkrhand@uni-tuebingen.de.

References

Related Letters:

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N Engl J Med 1999; 340:2004-2005, Jun 24, 1999. Correspondence

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