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Previous Volume 340:314-315 January 28, 1999 Number 4 Next

	Since this article has no abstract, we have provided an extract of the first 100 words of the full text and any section headings.

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The immune system can summon a variety of defenses against invaders from the outside. Among these deterrents are three types of killer lymphocytes that attack and lyse cellular targets. One type consists of cytotoxic, or CD8, T cells with /ß antigen receptors that interact with the HLA class I glycoproteins on nearly all cells. These HLA molecules bind to peptides derived from intracellular antigens, such as viral proteins, and display them on the cell surface. Binding of the /ß antigen receptor to complexes of HLA class I molecules and peptide fragments of an invading virus induces the T lymphocyte to . . . [Full Text of this Article]

References

Related Letters:

Pure Red-Cell Aplasia
Nathan D. G., Sieff C. A., Zimmer J., Regele D., de la Salle H., Handgretinger R., Fisch P.
Extract | Full Text  
N Engl J Med 1999; 340:2004-2005, Jun 24, 1999. Correspondence

This article has been cited by other articles:

• Nathan, D. G., Sieff, C. A., Zimmer, J., Regele, D., de la Salle, H., Handgretinger, R., Fisch, P. (1999). Pure Red-Cell Aplasia. NEJM 340: 2004-2005 [Full Text]