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Previous Volume 340:486-487 February 11, 1999 Number 6 Next

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By Robert Bazell. 214 pp. New York, Random House, 1998. $23.95. ISBN 0-679-45702-X.

This book describes the development of a new type of therapy for breast cancer, from the discovery of the molecular target to the completion of successful randomized, clinical trials and approval for use.

It is written as the story of the triumph of an inspired clinician against great opposition, which included his own colleagues, grant-awarding agencies, and pharmaceutical companies. There is no doubt that Dennis Slamon discovered the role of the erbB2 (her2) oncogene in breast and ovarian cancer and played a major part in preclinical studies that showed that inhibition of this molecular target was worthwhile. He . . . [Full Text of this Article]

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