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Previous Volume 340:559-561 February 18, 1999 Number 7 Next

	Since this article has no abstract, we have provided an extract of the first 100 words of the full text and any section headings.

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It has been 30 years since the first patient with combined T-cell and B-cell immunodeficiency was successfully treated with transplantation of bone marrow from an HLA-identical sibling.¹ Since then, hundreds of patients with severe combined immunodeficiency have been cured by the transplantation of hematopoietic progenitor cells from either a sibling or a parent who was HLA-haploincompatible (also called HLA-haploidentical, meaning that one of the two HLA haplotypes of the parent matches one of the child's, but the other parental HLA haplotype does not). Many of these patients are now long-term survivors. During the same period, the molecular basis for most . . . [Full Text of this Article]

References

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