Although its incidence has declined in the past decade, hepatitisA is still responsible for nearly 60 percent of the cases ofacute viral hepatitis in the United States. In about half thesecases, no source of infection is identified. The investigationof a far-flung, foodborne outbreak of hepatitis A from a commonsource described by Hutin et al. in this issue of the Journal1is a superb example of "shoe-leather" epidemiology combinedwith molecular sequencing to establish the genetic relatednessof hepatitis A virus (HAV) isolates. Classic casecontroland cohort studies of food consumed during the probable periodof . . . [Full Text of this Article]
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