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Correspondence
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Volume 340:655-656 February 25, 1999 Number 8
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Anal Pruritus after Cancer Chemotherapy with Gemcitabine

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To the Editor: A 57-year-old man with a diagnosis of advanced, inoperable pancreatic cancer received palliative treatment consisting of gemcitabine (1000 mg per square meter of body-surface area given intravenously on days 1, 8, and 15) with antagonists to 5-hydroxytryptamine3 receptors used as antiemetic prophylaxis. During the second infusion, the patient reported severe anal pruritus. The itching subsided 10 minutes after the infusion was stopped but promptly recurred after the reinstitution of treatment. When questioned, the patient said that he had also experienced itching during the first infusion, which he was embarrassed to tell anyone about in the presence of . . . [Full Text of this Article]

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