FREE NEJM E-TOC    HOME   |   SUBSCRIBE   |   CURRENT ISSUE   |   PAST ISSUES   |   COLLECTIONS   |   Search Term  Advanced Search

Sign in | Get NEJM's E-Mail Table of Contents — Free | Subscribe

Previous Volume 340:737-738 March 4, 1999 Number 9 Next

/ T-Cell Stimulation by Pamidronate

	Since this article has no abstract, we have provided an extract of the first 100 words of the full text and any section headings.

	Full Text Purchase this article Add to Personal Archive Add to Citation Manager Notify a Friend E-mail When Cited PubMed Citation

To the Editor: Bisphosphonates are widely used to inhibit osteoclastic bone resorption. As analogues of pyrophosphate they share several structural homologies with recently identified non-peptide / T-cell ligands, such as isopentenyl pyrophosphate, that activate antigenic receptors of / T cells.¹

We recently found that aminobisphosphonates (pamidronate, ibandronate, and alendronate) can stimulate the major subgroup of / T cells in peripheral blood (V9V2+ T cells), whereas non-aminobisphosphonates (clodronate and etidronate) are inactive. In our assays, pamidronate (concentration yielding half-maximal activity, 5 to 10 µM) induced the activation and selective expansion of / T cells in cultures of peripheral-blood mononuclear . . . [Full Text of this Article]

References

This article has been cited by other articles:

• Li, J., Herold, M. J., Kimmel, B., Muller, I., Rincon-Orozco, B., Kunzmann, V., Herrmann, T. (2009). Reduced Expression of the Mevalonate Pathway Enzyme Farnesyl Pyrophosphate Synthase Unveils Recognition of Tumor Cells by V{gamma}9V{delta}2 T Cells. J. Immunol. 182: 8118-8124 [Abstract] [Full Text]  
• Todaro, M., D'Asaro, M., Caccamo, N., Iovino, F., Francipane, M. G., Meraviglia, S., Orlando, V., La Mendola, C., Gulotta, G., Salerno, A., Dieli, F., Stassi, G. (2009). Efficient Killing of Human Colon Cancer Stem Cells by {gamma}{delta} T Lymphocytes. J. Immunol. 182: 7287-7296 [Abstract] [Full Text]  
• Agrati, C., Cimini, E., Sacchi, A., Bordoni, V., Gioia, C., Casetti, R., Turchi, F., Tripodi, M., Martini, F. (2009). Activated V{gamma}9V{delta}2 T Cells Trigger Granulocyte Functions via MCP-2 Release. J. Immunol. 182: 522-529 [Abstract] [Full Text]  
• Sharma, N. S., Ooi, J.-L., Masselos, K., Hooper, M. J., Francis, I. C. (2008). Zoledronic Acid Infusion and Orbital Inflammatory Disease. NEJM 359: 1410-1411 [Full Text]  
• Takahara, M., Miyai, M., Tomiyama, M., Mutou, M., Nicol, A. J., Nieda, M. (2008). Copulsing tumor antigen-pulsed dendritic cells with zoledronate efficiently enhance the expansion of tumor antigen-specific CD8+ T cells via V{gamma}9{gamma}{delta} T cell activation. J. Leukoc. Biol. 83: 742-754 [Abstract] [Full Text]  
• Olson, K., Van Poznak, C. (2007). Significance and impact of bisphosphonate-induced acute phase responses. J Oncol Pharm Pract 13: 223-229 [Abstract]  
• Holderness, J., Jackiw, L., Kimmel, E., Kerns, H., Radke, M., Hedges, J. F., Petrie, C., McCurley, P., Glee, P. M., Palecanda, A., Jutila, M. A. (2007). Select Plant Tannins Induce IL-2R{alpha} Up-Regulation and Augment Cell Division in {gamma}{delta} T Cells. J. Immunol. 179: 6468-6478 [Abstract] [Full Text]  
• Santini, D, Vincenzi, B, Caraglia, M, Tonini, G (2007). A hitherto unreported high incidence of zoledronic acid-induced acute phase reaction in patients with cancer treatment-induced bone loss. Ann Oncol 18: 201-202 [Full Text]  
• Caccamo, N., Battistini, L., Bonneville, M., Poccia, F., Fournie, J. J., Meraviglia, S., Borsellino, G., Kroczek, R. A., La Mendola, C., Scotet, E., Dieli, F., Salerno, A. (2006). CXCR5 Identifies a Subset of V{gamma}9V{delta}2 T Cells which Secrete IL-4 and IL-10 and Help B Cells for Antibody Production. J. Immunol. 177: 5290-5295 [Abstract] [Full Text]  
• Roelofs, A. J., Thompson, K., Gordon, S., Rogers, M. J. (2006). Molecular mechanisms of action of bisphosphonates: current status.. Clin. Cancer Res. 12: 6222s-6230s [Abstract] [Full Text]  
• Thompson, K., Rogers, M. J. (2006). Bisphosphonates and {gamma}{delta} T-Cells: New Insights into Old Drugs. IBMS BoneKEy 3: 5-13 [Abstract] [Full Text]  
• Tanvetyanon, T., Stiff, P. J. (2006). Management of the adverse effects associated with intravenous bisphosphonates. Ann Oncol 17: 897-907 [Abstract] [Full Text]  
• Devilder, M.-C., Maillet, S., Bouyge-Moreau, I., Donnadieu, E., Bonneville, M., Scotet, E. (2006). Potentiation of Antigen-Stimulated V{gamma}9V{delta}2 T Cell Cytokine Production by Immature Dendritic Cells (DC) and Reciprocal Effect on DC Maturation. J. Immunol. 176: 1386-1393 [Abstract] [Full Text]  
• Thompson, K., Rojas-Navea, J., Rogers, M. J. (2006). Alkylamines cause V{gamma}9V{delta}2 T-cell activation and proliferation by inhibiting the mevalonate pathway. Blood 107: 651-654 [Abstract] [Full Text]  
• Agrati, C., Alonzi, T., De Santis, R., Castilletti, C., Abbate, I., Capobianchi, M. R., D'Offizi, G., Siepi, F., Fimia, G. M., Tripodi, M., Poccia, F. (2006). Activation of V{gamma}9V{delta}2 T cells by non-peptidic antigens induces the inhibition of subgenomic HCV replication. Int Immunol 18: 11-18 [Abstract] [Full Text]  
• Collins, C., Wolfe, J., Roessner, K., Shi, C., Sigal, L. H., Budd, R. C. (2005). Lyme Arthritis Synovial {gamma}{delta} T Cells Instruct Dendritic Cells via Fas Ligand. J. Immunol. 175: 5656-5665 [Abstract] [Full Text]  
• Sicard, H., Ingoure, S., Luciani, B., Serraz, C., Fournie, J.-J., Bonneville, M., Tiollier, J., Romagne, F. (2005). In Vivo Immunomanipulation of V{gamma}9V{delta}2 T Cells with a Synthetic Phosphoantigen in a Preclinical Nonhuman Primate Model. J. Immunol. 175: 5471-5480 [Abstract] [Full Text]  
• Corvaisier, M., Moreau-Aubry, A., Diez, E., Bennouna, J., Mosnier, J.-F., Scotet, E., Bonneville, M., Jotereau, F. (2005). V{gamma}9V{delta}2 T Cell Response to Colon Carcinoma Cells. J. Immunol. 175: 5481-5488 [Abstract] [Full Text]  
• Casetti, R., Perretta, G., Taglioni, A., Mattei, M., Colizzi, V., Dieli, F., D'Offizi, G., Malkovsky, M., Poccia, F. (2005). Drug-Induced Expansion and Differentiation of V{gamma}9V{delta}2 T Cells In Vivo: The Role of Exogenous IL-2. J. Immunol. 175: 1593-1598 [Abstract] [Full Text]  
• Conti, L., Casetti, R., Cardone, M., Varano, B., Martino, A., Belardelli, F., Poccia, F., Gessani, S. (2005). Reciprocal Activating Interaction Between Dendritic Cells and Pamidronate-Stimulated {gamma}{delta} T Cells: Role of CD86 and Inflammatory Cytokines. J. Immunol. 174: 252-260 [Abstract] [Full Text]  
• Kabelitz, D., Wesch, D., Pitters, E., Zoller, M. (2004). Characterization of Tumor Reactivity of Human V{gamma}9V{delta}2 {gamma}{delta} T Cells In Vitro and in SCID Mice In Vivo. J. Immunol. 173: 6767-6776 [Abstract] [Full Text]  
• Angelini, D. F., Borsellino, G., Poupot, M., Diamantini, A., Poupot, R., Bernardi, G., Poccia, F., Fournie, J.-J., Battistini, L. (2004). Fc{gamma}RIII discriminates between 2 subsets of V{gamma}9V{delta}2 effector cells with different responses and activation pathways. Blood 104: 1801-1807 [Abstract] [Full Text]  
• Das, H., Sugita, M., Brenner, M. B. (2004). Mechanisms of V{delta}1 {gamma}{delta} T Cell Activation by Microbial Components. J. Immunol. 172: 6578-6586 [Abstract] [Full Text]  
• Yamashita, S., Tanaka, Y., Harazaki, M., Mikami, B., Minato, N. (2003). Recognition mechanism of non-peptide antigens by human {gamma}{delta} T cells. Int Immunol 15: 1301-1307 [Abstract] [Full Text]  
• Santini, D., Vespasiani Gentilucci, U., Vincenzi, B., Picardi, A., Vasaturo, F., La Cesa, A., Onori, N., Scarpa, S., Tonini, G. (2003). The antineoplastic role of bisphosphonates: from basic research to clinical evidence. Ann Oncol 14: 1468-1476 [Abstract] [Full Text]  
• Subramanian, P. S., Kerrison, J. B., Calvert, P. C., Miller, N. R. (2003). Orbital Inflammatory Disease After Pamidronate Treatment for Metastatic Prostate Cancer. Arch Ophthalmol 121: 1335-1336 [Full Text]  
• Dieli, F., Poccia, F., Lipp, M., Sireci, G., Caccamo, N., Di Sano, C., Salerno, A. (2003). Differentiation of Effector/Memory V{delta}2 T Cells and Migratory Routes in Lymph Nodes or Inflammatory Sites. JEM 198: 391-397 [Abstract] [Full Text]  
• Wilhelm, M., Kunzmann, V., Eckstein, S., Reimer, P., Weissinger, F., Ruediger, T., Tony, H.-P. (2003). {gamma}{delta} T cells for immune therapy of patients with lymphoid malignancies. Blood 102: 200-206 [Abstract] [Full Text]  
• Kato, Y., Tanaka, Y., Tanaka, H., Yamashita, S., Minato, N. (2003). Requirement of Species-Specific Interactions for the Activation of Human {gamma}{delta} T Cells by Pamidronate. J. Immunol. 170: 3608-3613 [Abstract] [Full Text]  
• Wang, H., Lee, H. K., Bukowski, J. F., Li, H., Mariuzza, R. A., Chen, Z. W., Nam, K.-H., Morita, C. T. (2003). Conservation of Nonpeptide Antigen Recognition by Rhesus Monkey V{gamma}2V{delta}2 T Cells. J. Immunol. 170: 3696-3706 [Abstract] [Full Text]  
• Zhou, D., Lai, X., Shen, Y., Sehgal, P., Shen, L., Simon, M., Qiu, L., Huang, D., Du, G. Z., Wang, Q., Letvin, N. L., Chen, Z. W. (2003). Inhibition of Adaptive V{gamma}2V{delta}2+ T-Cell Responses during Active Mycobacterial Coinfection of Simian Immunodeficiency Virus SIVmac-Infected Monkeys. J. Virol. 77: 2998-3006 [Abstract] [Full Text]  
• Wang, L., Das, H., Kamath, A., Li, L., Bukowski, J. F. (2002). Human V{gamma}2V{delta}2 T Cells Augment Migration-Inhibitory Factor Secretion and Counteract the Inhibitory Effect of Glucocorticoids on IL-1{beta} and TNF-{alpha} Production. J. Immunol. 168: 4889-4896 [Abstract] [Full Text]  
• Shen, Y., Zhou, D., Qiu, L., Lai, X., Simon, M., Shen, L., Kou, Z., Wang, Q., Jiang, L., Estep, J., Hunt, R., Clagett, M., Sehgal, P. K., Li, Y., Zeng, X., Morita, C. T., Brenner, M. B., Letvin, N. L., Chen, Z. W. (2002). Adaptive Immune Response of Vgamma 2Vdelta 2+ T Cells During Mycobacterial Infections. Science 295: 2255-2258 [Abstract] [Full Text]  
• Gioia, C., Agrati, C., Casetti, R., Cairo, C., Borsellino, G., Battistini, L., Mancino, G., Goletti, D., Colizzi, V., Pucillo, L. P., Poccia, F. (2002). Lack of CD27-CD45RA-V{gamma}9V{delta}2+ T Cell Effectors in Immunocompromised Hosts and During Active Pulmonary Tuberculosis. J. Immunol. 168: 1484-1489 [Abstract] [Full Text]  
• Miyagawa, F., Tanaka, Y., Yamashita, S., Mikami, B., Danno, K., Uehara, M., Minato, N. (2001). Essential Contribution of Germline-Encoded Lysine Residues in J{gamma}1.2 Segment to the Recognition of Nonpeptide Antigens by Human {gamma}{delta} T Cells. J. Immunol. 167: 6773-6779 [Abstract] [Full Text]  
• Kato, Y., Tanaka, Y., Miyagawa, F., Yamashita, S., Minato, N. (2001). Targeting of Tumor Cells for Human {gamma}{delta} T Cells by Nonpeptide Antigens. J. Immunol. 167: 5092-5098 [Abstract] [Full Text]  
• Das, H., Wang, L., Kamath, A., Bukowski, J. F. (2001). V{gamma}2V{delta}2 T-cell receptor-mediated recognition of aminobisphosphonates. Blood 98: 1616-1618 [Abstract] [Full Text]  
• Ryan, P. J., Sampath, R. (2001). Idiopathic orbital inflammation following intravenous pamidronate. Rheumatology (Oxford) 40: 956-957 [Full Text]  
• Miyagawa, F., Tanaka, Y., Yamashita, S., Minato, N. (2001). Essential Requirement of Antigen Presentation by Monocyte Lineage Cells for the Activation of Primary Human {{gamma}}{{delta}} T Cells by Aminobisphosphonate Antigen. J. Immunol. 166: 5508-5514 [Abstract] [Full Text]  
• Schilbach, K., Geiselhart, A., Handgretinger, R. (2001). Induction of proliferation and augmented cytotoxicity of gamma delta T lymphocytes by bisphosphonate clodronate. Blood 97: 2917-2917 [Full Text]  
• Kunzmann, V., Bauer, E., Feurle, J., Tony, F. W.{b.}i. H.-P., Wilhelm, M. (2000). Stimulation of gamma delta T cells by aminobisphosphonates and induction of antiplasma cell activity in multiple myeloma. Blood 96: 384-392 [Abstract] [Full Text]