FREE NEJM E-TOC    HOME   |   SUBSCRIBE   |   CURRENT ISSUE   |   PAST ISSUES   |   COLLECTIONS   |   Search Term  Advanced Search

Sign in | Get NEJM's E-Mail Table of Contents — Free | Subscribe

Previous Volume 340:738-739 March 4, 1999 Number 9 Next

	Since this article has no abstract, we have provided an extract of the first 100 words of the full text and any section headings.

	Full Text Purchase this article Add to Personal Archive Add to Citation Manager Notify a Friend E-mail When Cited Related Article by Cleveland, R. H. PubMed Citation

To the Editor: It is unknown why monozygotic twins are more frequent in conceptions brought about by assisted-reproduction techniques.^1,2,3,4 One hypothesis is that the exposure of the zona pellucida to biochemical or mechanical trauma leads to herniation of the blastocyst and cleavage of the zygote. This possibility is not only of biologic importance in understanding spontaneous monozygotic twinning but is a major area of clinical concern, primarily because of the confirmed increase in morbidity and mortality associated with monozygotic twinning.

A zygote may split anytime during the first 14 days after fertilization, resulting in the various forms of monozygotic twins. . . . [Full Text of this Article]

References

This article has been cited by other articles:

• Vitthala, S., Gelbaya, T.A., Brison, D.R., Fitzgerald, C.T., Nardo, L.G. (2008). The risk of monozygotic twins after assisted reproductive technology: a systematic review and meta-analysis. Hum Reprod Update 0: dmn045v1-10 [Abstract] [Full Text]  
• Aston, K I, Peterson, C M, Carrell, D T (2008). Monozygotic twinning associated with assisted reproductive technologies: a review. Reproduction 136: 377-386 [Abstract] [Full Text]  
• Pinborg, A. (2005). IVF/ICSI twin pregnancies: risks and prevention. Hum Reprod Update 11: 575-593 [Abstract] [Full Text]  
• Maher, E. R. (2005). Imprinting and assisted reproductive technology. Hum Mol Genet 14: R133-R138 [Abstract] [Full Text]  
• Williams, C.A., Wallace, M.R., Drury, K.C., Kipersztok, S., Edwards, R.K., Williams, R.S., Haller, M.J., Schatz, D.A., Silverstein, J.H., Gray, B.A., Zori, R.T. (2004). Blood lymphocyte chimerism associated with IVF and monochorionic dizygous twinning: Case report. Hum Reprod 19: 2816-2821 [Abstract] [Full Text]  
• Schieve, L. A., Rasmussen, S. A., Buck, G. M., Schendel, D. E., Reynolds, M. A., Wright, V. C. (2004). Are Children Born After Assisted Reproductive Technology at Increased Risk for Adverse Health Outcomes?. Obstet Gynecol 103: 1154-1163 [Abstract] [Full Text]  
• Schieve, L. A., Reynolds, M. A. (2004). What is the most relevant standard of success in assisted reproduction?: Challenges in measuring and reporting success rates for assisted reproductive technology treatments: What is optimal?. Hum Reprod 19: 778-782 [Abstract] [Full Text]  
• Alikani, M., Cekleniak, N. A., Walters, E., Cohen, J. (2003). Monozygotic twinning following assisted conception: an analysis of 81 consecutive cases. Hum Reprod 18: 1937-1943 [Abstract] [Full Text]  
• Souter, V. L., Kapur, R. P., Nyholt, D. R., Skogerboe, K., Myerson, D., Ton, C. C., Opheim, K. E., Easterling, T. R., Shields, L. E., Montgomery, G. W., Glass, I. A. (2003). A Report of Dizygous Monochorionic Twins. NEJM 349: 154-158 [Full Text]  
• Blickstein, I., Jones, C., Keith, L. G. (2003). Zygotic-Splitting Rates after Single-Embryo Transfers in in Vitro Fertilization. NEJM 348: 2366-2367 [Full Text]