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The classification of lymphomas has been a challenge to our intellect and to our science. Over the past 40 years, we have moved through numerous classification schemes, which have varied in usefulness. Some schemes were purely morphologic classifications with some clinical implications, such as those based on whether the tumor cells were small, medium, or large lymphocytes (e.g., the Rappaport classification). Others have been more clinically oriented and have encompassed a number of different morphologic types; for example, in the Working Formulation, lymphomas were grouped into low, intermediate, and high grades according to their clinical behavior. High-grade lymphomas included both
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