Cutaneous Wound Healing

doi:10.1056/NEJM199909023411006

Volume 341:738-746		September 2, 1999		Number 10

Cutaneous Wound Healing

Adam J. Singer, M.D., and Richard A.F. Clark, M.D.

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The primary function of the skin is to serve as a protectivebarrier against the environment. Loss of the integrity of largeportions of the skin as a result of injury or illness may leadto major disability or even death. Every year in the UnitedStates more than 1.25 million people have burns¹ and 6.5 millionhave chronic skin ulcers caused by pressure, venous stasis,or diabetes mellitus.²

The primary goals of the treatment of wounds are rapid woundclosure and a functional and aesthetically satisfactory scar.Recent advances in cellular and molecular biology have greatlyexpanded our understanding . . . [Full Text of this Article]

Biology of Wound Healing

Inflammation

Epithelialization

Formation of Granulation Tissue

Neovascularization

Wound Contraction and Extracellular-Matrix Reorganization

Abnormal Wound Healing

Clinical Experience with Growth Factors

Insights from Fetal Wound Healing

Skin Substitutes

Epidermal Skin Substitutes

Dermal Skin Substitutes

Combined Dermal and Epidermal Skin Substitutes

Clinical Implications

Source Information

From the Departments of Emergency Medicine (A.J.S.) and Dermatology (R.A.F.C.), State University of New York at Stony Brook, Stony Brook.

Address reprint requests to Dr. Singer at the Department of Emergency Medicine, University Medical Center, State University of New York at Stony Brook, Stony Brook, NY 11794-8350.

References

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Saravanan, C., Cao, Z., Head, S. R, Panjwani, N. (2010). Analysis of differential expression of glycosyltransferases in healing corneas by glycogene microarrays. Glycobiology 20: 13-23 [Abstract] [Full Text]
Mirza, R., DiPietro, L. A., Koh, T. J. (2009). Selective and Specific Macrophage Ablation Is Detrimental to Wound Healing in Mice. Am. J. Pathol. 175: 2454-2462 [Abstract] [Full Text]
Upadhyay, N. K., Kumar, R., Siddiqui, M.S., Gupta, A. (2009). Mechanism of Wound-Healing Activity of Hippophae rhamnoides L. Leaf Extract in Experimental Burns. Evid Based Complement Alternat Med 0: nep189v1-nep189 [Abstract] [Full Text]
Stout, R. D., Watkins, S. K., Suttles, J. (2009). Functional plasticity of macrophages: in situ reprogramming of tumor-associated macrophages. J. Leukoc. Biol. 86: 1105-1109 [Abstract] [Full Text]
Radek, K. A., Ranzer, M. J., DiPietro, L. A. (2009). Brewing complications: the effect of acute ethanol exposure on wound healing. J. Leukoc. Biol. 86: 1125-1134 [Abstract] [Full Text]
Kim, T.-i., Chung, J. L., Hong, J. P., Min, K., Seo, K. Y., Kim, E. K. (2009). Bevacizumab Application Delays Epithelial Healing in Rabbit Cornea. IOVS 50: 4653-4659 [Abstract] [Full Text]
Malavia, N. K., Raub, C. B., Mahon, S. B., Brenner, M., Panettieri, R. A. Jr., George, S. C. (2009). Airway Epithelium Stimulates Smooth Muscle Proliferation. Am. J. Respir. Cell Mol. Bio. 41: 297-304 [Abstract] [Full Text]
Sabeh, F., Li, X.-Y., Saunders, T. L., Rowe, R. G., Weiss, S. J. (2009). Secreted Versus Membrane-anchored Collagenases: RELATIVE ROLES IN FIBROBLAST-DEPENDENT COLLAGENOLYSIS AND INVASION. J. Biol. Chem. 284: 23001-23011 [Abstract] [Full Text]
Jinno, K., Takahashi, T., Tsuchida, K., Tanaka, E., Moriyama, K. (2009). Acceleration of Palatal Wound Healing in Smad3-deficient Mice. JDR 88: 757-761 [Abstract] [Full Text]
Iwata, Y., Yoshizaki, A., Komura, K., Shimizu, K., Ogawa, F., Hara, T., Muroi, E., Bae, S., Takenaka, M., Yukami, T., Hasegawa, M., Fujimoto, M., Tomita, Y., Tedder, T. F., Sato, S. (2009). CD19, a Response Regulator of B Lymphocytes, Regulates Wound Healing through Hyaluronan-Induced TLR4 Signaling. Am. J. Pathol. 175: 649-660 [Abstract] [Full Text]
Hattori, N., Mochizuki, S., Kishi, K., Nakajima, T., Takaishi, H., D'Armiento, J., Okada, Y. (2009). MMP-13 Plays a Role in Keratinocyte Migration, Angiogenesis, and Contraction in Mouse Skin Wound Healing. Am. J. Pathol. 175: 533-546 [Abstract] [Full Text]
Swirski, F. K., Nahrendorf, M., Etzrodt, M., Wildgruber, M., Cortez-Retamozo, V., Panizzi, P., Figueiredo, J.-L., Kohler, R. H., Chudnovskiy, A., Waterman, P., Aikawa, E., Mempel, T. R., Libby, P., Weissleder, R., Pittet, M. J. (2009). Identification of Splenic Reservoir Monocytes and Their Deployment to Inflammatory Sites. Science 325: 612-616 [Abstract] [Full Text]
Zheng, L., Zhou, Z., Lin, L., Alber, S., Watkins, S., Kaminski, N., Choi, A. M. K., Morse, D. (2009). Carbon Monoxide Modulates {alpha}-Smooth Muscle Actin and Small Proline Rich-1a Expression in Fibrosis. Am. J. Respir. Cell Mol. Bio. 41: 85-92 [Abstract] [Full Text]
Goren, I., Allmann, N., Yogev, N., Schurmann, C., Linke, A., Holdener, M., Waisman, A., Pfeilschifter, J., Frank, S. (2009). A Transgenic Mouse Model of Inducible Macrophage Depletion: Effects of Diphtheria Toxin-Driven Lysozyme M-Specific Cell Lineage Ablation on Wound Inflammatory, Angiogenic, and Contractive Processes. Am. J. Pathol. 175: 132-147 [Abstract] [Full Text]
Eslami, A., Gallant-Behm, C. L., Hart, D. A., Wiebe, C., Honardoust, D., Gardner, H., Hakkinen, L., Larjava, H. S. (2009). Expression of Integrin {alpha}v{beta}6 and TGF-{beta} in Scarless vs Scar-forming Wound Healing. J. Histochem. Cytochem. 57: 543-557 [Abstract] [Full Text]
Mitchell, K., Szekeres, C., Milano, V., Svenson, K. B., Nilsen-Hamilton, M., Kreidberg, J. A., DiPersio, C. M. (2009). {alpha}3{beta}1 integrin in epidermis promotes wound angiogenesis and keratinocyte-to-endothelial-cell crosstalk through the induction of MRP3. J. Cell Sci. 122: 1778-1787 [Abstract] [Full Text]
Carvajal-Gonzalez, J. M., Roman, A. C., Cerezo-Guisado, M. I., Rico-Leo, E. M., Martin-Partido, G., Fernandez-Salguero, P. M. (2009). Loss of dioxin-receptor expression accelerates wound healing in vivo by a mechanism involving TGF{beta}. J. Cell Sci. 122: 1823-1833 [Abstract] [Full Text]
Tie, L., Li, X.-J., Wang, X., Channon, K. M., Chen, A. F. (2009). Endothelium-specific GTP cyclohydrolase I overexpression accelerates refractory wound healing by suppressing oxidative stress in diabetes. Am. J. Physiol. Endocrinol. Metab. 296: E1423-E1429 [Abstract] [Full Text]
Sindrilaru, A., Peters, T., Schymeinsky, J., Oreshkova, T., Wang, H., Gompf, A., Mannella, F., Wlaschek, M., Sunderkotter, C., Rudolph, K. L., Walzog, B., Bustelo, X. R., Fischer, K. D., Scharffetter-Kochanek, K. (2009). Wound healing defect of Vav3-/- mice due to impaired {beta}2-integrin-dependent macrophage phagocytosis of apoptotic neutrophils. Blood 113: 5266-5276 [Abstract] [Full Text]
Kutsukake, M., Shibao, H., Uematsu, K., Fukatsu, T. (2009). Scab formation and wound healing of plant tissue by soldier aphid. Proc R Soc B 276: 1555-1563 [Abstract] [Full Text]
Bhushan, B. (2009). Biomimetics: lessons from nature-an overview. Phil Trans R Soc A 367: 1445-1486 [Abstract] [Full Text]
MacLauchlan, S., Skokos, E. A., Agah, A., Zeng, J., Tian, W., Davidson, J. M., Bornstein, P., Kyriakides, T. R. (2009). Enhanced Angiogenesis and Reduced Contraction in Thrombospondin-2-null Wounds Is Associated With Increased Levels of Matrix Metalloproteinases-2 and -9, and Soluble VEGF. J. Histochem. Cytochem. 57: 301-313 [Abstract] [Full Text]
Kaitu'u-Lino, T. J., Phillips, D. J., Morison, N. B., Salamonsen, L. A. (2009). A New Role for Activin in Endometrial Repair after Menses. Endocrinology 150: 1904-1911 [Abstract] [Full Text]
Kim, M.-H., Curry, F.-R. E., Simon, S. I. (2009). Dynamics of neutrophil extravasation and vascular permeability are uncoupled during aseptic cutaneous wounding. Am. J. Physiol. Cell Physiol. 296: C848-C856 [Abstract] [Full Text]
Frykberg, R., Tierney, E., Tallis, A., Klotzbach, T. (2009). Cell Proliferation Induction: Healing Chronic Wounds Through Low-Energy Pulsed Radiofrequency. INT J LOW EXTREM WOUNDS 8: 45-51 [Abstract]
Cardoso, J. F., Mendes, F. A., Amadeu, T. P., Romana-Souza, B., Valenca, S. S., de Moraes Sobrino Porto, L. C., Abreu, J. G., Monte-Alto-Costa, A. (2009). Ccn2/Ctgf Overexpression Induced by Cigarette Smoke during Cutaneous Wound Healing is Strain Dependent. Toxicol Pathol 37: 175-182 [Abstract] [Full Text]
Underwood, R. A., Carter, W. G., Usui, M. L., Olerud, J. E. (2009). Ultrastructural Localization of Integrin Subunits {beta}4 and {alpha}3 Within the Migrating Epithelial Tongue of In Vivo Human Wounds. J. Histochem. Cytochem. 57: 123-142 [Abstract] [Full Text]
Weiger, M. C., Wang, C.-C., Krajcovic, M., Melvin, A. T., Rhoden, J. J., Haugh, J. M. (2009). Spontaneous phosphoinositide 3-kinase signaling dynamics drive spreading and random migration of fibroblasts. J. Cell Sci. 122: 313-323 [Abstract] [Full Text]
Klass, B R, Grobbelaar, A O, Rolfe, K J (2009). Transforming growth factor {beta}1 signalling, wound healing and repair: a multifunctional cytokine with clinical implications for wound repair, a delicate balance. Postgrad. Med. J. 85: 9-14 [Abstract] [Full Text]
D'Alessio, S., Gerasi, L., Blasi, F. (2008). uPAR-deficient mouse keratinocytes fail to produce EGFR-dependent laminin-5, affecting migration in vivo and in vitro. J. Cell Sci. 121: 3922-3932 [Abstract] [Full Text]
Pietramaggiori, G., Scherer, S. S., Cervi, D., Klement, G., Orgill, D. P. (2008). Tumors Stimulate Platelet Delivery of Angiogenic Factors in Vivo: An Unexpected Benefit. Am. J. Pathol. 173: 1609-1616 [Abstract] [Full Text]
Aden, N., Shiwen, X., Aden, D., Black, C., Nuttall, A., Denton, C. P., Leask, A., Abraham, D., Stratton, R. (2008). Proteomic analysis of scleroderma lesional skin reveals activated wound healing phenotype of epidermal cell layer. Rheumatology (Oxford) 47: 1754-1760 [Abstract] [Full Text]
Morris, M. A., Dawson, C. W., Wei, W., O'Neil, J. D., Stewart, S. E., Jia, J., Bell, A. I., Young, L. S., Arrand, J. R. (2008). Epstein-Barr virus-encoded LMP1 induces a hyperproliferative and inflammatory gene expression programme in cultured keratinocytes. J. Gen. Virol. 89: 2806-2820 [Abstract] [Full Text]
He, H., Li, W., Chen, S.-Y., Zhang, S., Chen, Y.-T., Hayashida, Y., Zhu, Y.-T., Tseng, S. C. G. (2008). Suppression of Activation and Induction of Apoptosis in RAW264.7 Cells by Amniotic Membrane Extract. IOVS 49: 4468-4475 [Abstract] [Full Text]
Schiefelbein, D., Seitz, O., Goren, I., Dissmann, J. P., Schmidt, H., Bachmann, M., Sader, R., Geisslinger, G., Pfeilschifter, J., Frank, S. (2008). Keratinocyte-Derived Vascular Endothelial Growth Factor Biosynthesis Represents a Pleiotropic Side Effect of Peroxisome Proliferator-Activated Receptor-{gamma} Agonist Troglitazone but Not Rosiglitazone and Involves Activation of p38 Mitogen-Activated Protein Kinase: Implications for Diabetes-Impaired Skin Repair. Mol. Pharmacol. 74: 952-963 [Abstract] [Full Text]
Fan, X., Krieg, S., Kuo, C. J., Wiegand, S. J., Rabinovitch, M., Druzin, M. L., Brenner, R. M., Giudice, L. C., Nayak, N. R. (2008). VEGF blockade inhibits angiogenesis and reepithelialization of endometrium. FASEB J. 22: 3571-3580 [Abstract] [Full Text]
Kung, H.-N., Yang, M.-J., Chang, C.-F., Chau, Y.-P., Lu, K.-S. (2008). In vitro and in vivo wound healing-promoting activities of {beta}-lapachone. Am. J. Physiol. Cell Physiol. 295: C931-C943 [Abstract] [Full Text]
Meng, F., Cheng, X., Yang, L., Hou, N., Yang, X., Meng, A. (2008). Accelerated re-epithelialization in Dpr2-deficient mice is associated with enhanced response to TGF{beta} signaling. J. Cell Sci. 121: 2904-2912 [Abstract] [Full Text]
Nanney, L. B., Woodrell, C. D., Greives, M. R., Cardwell, N. L., Pollins, A. C., Bancroft, T. A., Chesser, A., Michalak, M., Rahman, M., Siebert, J. W., Gold, L. I. (2008). Calreticulin Enhances Porcine Wound Repair by Diverse Biological Effects. Am. J. Pathol. 173: 610-630 [Abstract] [Full Text]
Hull, M. L., Escareno, C. R., Godsland, J. M., Doig, J. R., Johnson, C. M., Phillips, S. C., Smith, S. K., Tavare, S., Print, C. G., Charnock-Jones, D. S. (2008). Endometrial-Peritoneal Interactions during Endometriotic Lesion Establishment. Am. J. Pathol. 173: 700-715 [Abstract] [Full Text]
Lam, C.-F., Chang, P.-J., Huang, Y.-S., Sung, Y.-H., Huang, C.-C., Lin, M.-W., Liu, Y.-C., Tsai, Y.-C. (2008). Prolonged Use of High-Dose Morphine Impairs Angiogenesis and Mobilization of Endothelial Progenitor Cells in Mice. Anesth. Analg. 107: 686-692 [Abstract] [Full Text]
Usui, M. L., Mansbridge, J. N., Carter, W. G., Fujita, M., Olerud, J. E. (2008). Keratinocyte Migration, Proliferation, and Differentiation in Chronic Ulcers From Patients With Diabetes and Normal Wounds. J. Histochem. Cytochem. 56: 687-696 [Abstract] [Full Text]
El-Okdi, N., Smaili, S., Raju, V., Shidyak, A., Gupta, S., Fedorova, L., Elkareh, J., Periyasamy, S., Shapiro, A. P., Kahaleh, M. B., Malhotra, D., Xie, Z., Chin, K. V., Shapiro, J. I. (2008). Effects of cardiotonic steroids on dermal collagen synthesis and wound healing. J. Appl. Physiol. 105: 30-36 [Abstract] [Full Text]
Otteson, T. D., Sandulache, V. C., Barsic, M., DiSilvio, G. M., Hebda, P. A., Dohar, J. E. (2008). Acute and Chronic Changes in the Subglottis Induced by Graded Carbon Dioxide Laser Injury in the Rabbit Airway. Arch Otolaryngol Head Neck Surg 134: 694-702 [Abstract] [Full Text]
Radek, K. A., Kovacs, E. J., Gallo, R. L., DiPietro, L. A. (2008). Acute ethanol exposure disrupts VEGF receptor cell signaling in endothelial cells. Am. J. Physiol. Heart Circ. Physiol. 295: H174-H184 [Abstract] [Full Text]
Reitzel, A. M., Sullivan, J. C., Traylor-knowles, N., Finnerty, J. R. (2008). Genomic Survey of Candidate Stress-Response Genes in the Estuarine Anemone Nematostella vectensis. Biol. Bull. 214: 233-254 [Abstract] [Full Text]
Schiefelbein, D., Goren, I., Fisslthaler, B., Schmidt, H., Geisslinger, G., Pfeilschifter, J., Frank, S. (2008). Biphasic Regulation of HMG-CoA Reductase Expression and Activity during Wound Healing and Its Functional Role in the Control of Keratinocyte Angiogenic and Proliferative Responses. J. Biol. Chem. 283: 15479-15490 [Abstract] [Full Text]
Cheng, C.-F., Fan, J., Fedesco, M., Guan, S., Li, Y., Bandyopadhyay, B., Bright, A. M., Yerushalmi, D., Liang, M., Chen, M., Han, Y.-P., Woodley, D. T., Li, W. (2008). Transforming Growth Factor {alpha} (TGF{alpha})-Stimulated Secretion of HSP90{alpha}: Using the Receptor LRP-1/CD91 To Promote Human Skin Cell Migration against a TGF{beta}-Rich Environment during Wound Healing. Mol. Cell. Biol. 28: 3344-3358 [Abstract] [Full Text]
Radek, K. A., Baer, L. A., Eckhardt, J., DiPietro, L. A., Wade, C. E. (2008). Mechanical unloading impairs keratinocyte migration and angiogenesis during cutaneous wound healing. J. Appl. Physiol. 104: 1295-1303 [Abstract] [Full Text]
Yu, B. D., Mukhopadhyay, A., Wong, C. (2008). Skin and hair: models for exploring organ regeneration. Hum Mol Genet 17: R54-R59 [Abstract] [Full Text]
Hollinger, J. O., Hart, C. E., Hirsch, S. N., Lynch, S., Friedlaender, G. E. (2008). Recombinant Human Platelet-Derived Growth Factor: Biology and Clinical Applications. JBJS 90: 48-54 [Abstract] [Full Text]
Liu, S., Wang, H., Currie, B. M., Molinolo, A., Leung, H. J., Moayeri, M., Basile, J. R., Alfano, R. W., Gutkind, J. S., Frankel, A. E., Bugge, T. H., Leppla, S. H. (2008). Matrix Metalloproteinase-activated Anthrax Lethal Toxin Demonstrates High Potency in Targeting Tumor Vasculature. J. Biol. Chem. 283: 529-540 [Abstract] [Full Text]
Sloan, J (2008). Soft tissue injuries: introduction and basic principles. Emerg. Med. J. 25: 33-37 [Abstract] [Full Text]
Horowitz, J. C., Rogers, D. S., Simon, R. H., Sisson, T. H., Thannickal, V. J. (2008). Plasminogen Activation Induced Pericellular Fibronectin Proteolysis Promotes Fibroblast Apoptosis. Am. J. Respir. Cell Mol. Bio. 38: 78-87 [Abstract] [Full Text]
Ishida, Y., Gao, J.-L., Murphy, P. M. (2008). Chemokine Receptor CX3CR1 Mediates Skin Wound Healing by Promoting Macrophage and Fibroblast Accumulation and Function. J. Immunol. 180: 569-579 [Abstract] [Full Text]
Cardoso, J. F., Souza, B. R., Amadeu, T. P., Valenca, S. S., Porto, L. C. M. S., Costa, A. M. A. (2007). Effects of Cigarette Smoke in Mice Wound Healing is Strain Dependent. Toxicol Pathol 35: 890-896 [Abstract] [Full Text]
Taboubi, S., Milanini, J., Delamarre, E., Parat, F., Garrouste, F., Pommier, G., Takasaki, J., Hubaud, J.-C., Kovacic, H., Lehmann, M. (2007). G{alpha}(q/11)-coupled P2Y2 nucleotide receptor inhibits human keratinocyte spreading and migration. FASEB J. 21: 4047-4058 [Abstract] [Full Text]
Braiman-Wiksman, L., Solomonik, I., Spira, R., Tennenbaum, T. (2007). Novel Insights into Wound Healing Sequence of Events. Toxicol Pathol 35: 767-779 [Abstract] [Full Text]
Vaneau, M., Chaby, G., Guillot, B., Martel, P., Senet, P., Teot, L., Chosidow, O. (2007). Consensus Panel Recommendations for Chronic and Acute Wound Dressings. Arch Dermatol 143: 1291-1294 [Abstract] [Full Text]
Chaby, G., Senet, P., Vaneau, M., Martel, P., Guillaume, J.-C., Meaume, S., Teot, L., Debure, C., Dompmartin, A., Bachelet, H., Carsin, H., Matz, V., Richard, J. L., Rochet, J. M., Sales-Aussias, N., Zagnoli, A., Denis, C., Guillot, B., Chosidow, O. (2007). Dressings for Acute and Chronic Wounds: A Systematic Review. Arch Dermatol 143: 1297-1304 [Abstract] [Full Text]
Aarabi, S., Bhatt, K. A., Shi, Y., Paterno, J., Chang, E. I., Loh, S. A., Holmes, J. W., Longaker, M. T., Yee, H., Gurtner, G. C. (2007). Mechanical load initiates hypertrophic scar formation through decreased cellular apoptosis. FASEB J. 21: 3250-3261 [Abstract] [Full Text]
Yukami, T., Hasegawa, M., Matsushita, Y., Fujita, T., Matsushita, T., Horikawa, M., Komura, K., Yanaba, K., Hamaguchi, Y., Nagaoka, T., Ogawa, F., Fujimoto, M., Steeber, D. A., Tedder, T. F., Takehara, K., Sato, S. (2007). Endothelial selectins regulate skin wound healing in cooperation with L-selectin and ICAM-1. J. Leukoc. Biol. 82: 519-531 [Abstract] [Full Text]
Gutierrez-Fernandez, A., Inada, M., Balbin, M., Fueyo, A., Pitiot, A. S., Astudillo, A., Hirose, K., Hirata, M., Shapiro, S. D., Noel, A., Werb, Z., Krane, S. M., Lopez-Otin, C., Puente, X. S. (2007). Increased inflammation delays wound healing in mice deficient in collagenase-2 (MMP-8). FASEB J. 21: 2580-2591 [Abstract] [Full Text]
Kwon, A-H., Qiu, Z., Hirao, Y. (2007). Topical Application of Plasma Fibronectin in Full-Thickness Skin Wound Healing in Rats. Exp. Biol. Med. 232: 935-941 [Abstract] [Full Text]
Deiner, C., Shagdarsuren, E., Schwimmbeck, P. L., Rosenthal, P., Loddenkemper, C., Rauch, U., Pauschinger, M., Dietz, R., Schultheiss, H.-P., Dechend, R., Pels, K. (2007). Nf-{kappa}b and AP-1 activation is associated with late lumen loss after porcine coronary angioplasty and antiproliferative beta-irradiation. Cardiovasc Res 75: 195-204 [Abstract] [Full Text]
Agren, M. S., Werthen, M. (2007). The Extracellular Matrix in Wound Healing: A Closer Look at Therapeutics for Chronic Wounds. INT J LOW EXTREM WOUNDS 6: 82-97 [Abstract]
Grande-Garcia, A., Echarri, A., de Rooij, J., Alderson, N. B., Waterman-Storer, C. M., Valdivielso, J. M., del Pozo, M. A. (2007). Caveolin-1 regulates cell polarization and directional migration through Src kinase and Rho GTPases. JCB 177: 683-694 [Abstract] [Full Text]
Roos, N., Poulalhon, N., Farge, D., Madelaine, I., Mauviel, A., Verrecchia, F. (2007). In Vitro Evidence for a Direct Antifibrotic Role of the Immunosuppressive Drug Mycophenolate Mofetil. J. Pharmacol. Exp. Ther. 321: 583-589 [Abstract] [Full Text]
Chmielowiec, J., Borowiak, M., Morkel, M., Stradal, T., Munz, B., Werner, S., Wehland, J., Birchmeier, C., Birchmeier, W. (2007). c-Met is essential for wound healing in the skin. JCB 177: 151-162 [Abstract] [Full Text]
Blikslager, A. T., Moeser, A. J., Gookin, J. L., Jones, S. L., Odle, J. (2007). Restoration of Barrier Function in Injured Intestinal Mucosa. Physiol. Rev. 87: 545-564 [Abstract] [Full Text]
Sandulache, V. C., Chafin, J. B., Li-Korotky, H.-S., Otteson, T. D., Dohar, J. E., Hebda, P. A. (2007). Elucidating the Role of Interleukin 1beta and Prostaglandin E2 in Upper Airway Mucosal Wound Healing. Arch Otolaryngol Head Neck Surg 133: 365-374 [Abstract] [Full Text]
Maruyama, K., Asai, J., Ii, M., Thorne, T., Losordo, D. W., D'Amore, P. A. (2007). Decreased Macrophage Number and Activation Lead to Reduced Lymphatic Vessel Formation and Contribute to Impaired Diabetic Wound Healing. Am. J. Pathol. 170: 1178-1191 [Abstract] [Full Text]
Papanas, N., Maltezos, E. (2007). Growth Factors in the Treatment of Diabetic Foot Ulcers: New Technologies, Any Promises?. INT J LOW EXTREM WOUNDS 6: 37-53 [Abstract]
LaGier, A. J., Yoo, S. H., Alfonso, E. C., Meiners, S., Fini, M. E. (2007). Inhibition of Human Corneal Epithelial Production of Fibrotic Mediator TGF-{beta}2 by Basement Membrane-Like Extracellular Matrix. IOVS 48: 1061-1071 [Abstract] [Full Text]
Zheng, Y., Watanabe, M., Kuraishi, T., Hattori, S., Kai, C., Shibuya, M. (2007). Chimeric VEGF-ENZ7/PlGF Specifically Binding to VEGFR-2 Accelerates Skin Wound Healing via Enhancement of Neovascularization. Arterioscler. Thromb. Vasc. Bio. 27: 503-511 [Abstract] [Full Text]
Sa, S. M., Valdez, P. A., Wu, J., Jung, K., Zhong, F., Hall, L., Kasman, I., Winer, J., Modrusan, Z., Danilenko, D. M., Ouyang, W. (2007). The Effects of IL-20 Subfamily Cytokines on Reconstituted Human Epidermis Suggest Potential Roles in Cutaneous Innate Defense and Pathogenic Adaptive Immunity in Psoriasis. J. Immunol. 178: 2229-2240 [Abstract] [Full Text]
Mathieu, D. (2006). Role of Hyperbaric Oxygen Therapy in the Management of Lower Extremity Wounds. INT J LOW EXTREM WOUNDS 5: 233-235
Zhang, Y., Taveggia, C., Melendez-Vasquez, C., Einheber, S., Raine, C. S., Salzer, J. L., Brosnan, C. F., John, G. R. (2006). Interleukin-11 Potentiates Oligodendrocyte Survival and Maturation, and Myelin Formation.. J. Neurosci. 26: 12174-12185 [Abstract] [Full Text]
Giacco, F., Perruolo, G., D'Agostino, E., Fratellanza, G., Perna, E., Misso, S., Saldalamacchia, G., Oriente, F., Fiory, F., Miele, C., Formisano, S., Beguinot, F., Formisano, P. (2006). Thrombin-activated platelets induce proliferation of human skin fibroblasts by stimulating autocrine production of insulin-like growth factor-1. FASEB J. 20: 2402-2404 [Abstract] [Full Text]
Li, L., Heldin, C.-H., Heldin, P. (2006). Inhibition of Platelet-derived Growth Factor-BB-induced Receptor Activation and Fibroblast Migration by Hyaluronan Activation of CD44. J. Biol. Chem. 281: 26512-26519 [Abstract] [Full Text]
Cordier, J-F. (2006). Cryptogenic organising pneumonia.. Eur Respir J 28: 422-446 [Abstract] [Full Text]
Pullar, C. E., Rizzo, A., Isseroff, R. R. (2006). beta-Adrenergic Receptor Antagonists Accelerate Skin Wound Healing: EVIDENCE FOR A CATECHOLAMINE SYNTHESIS NETWORK IN THE EPIDERMIS. J. Biol. Chem. 281: 21225-21235 [Abstract] [Full Text]
Pilling, D., Tucker, N. M., Gomer, R. H. (2006). Aggregated IgG inhibits the differentiation of human fibrocytes. J. Leukoc. Biol. 79: 1242-1251 [Abstract] [Full Text]
Asai, J., Takenaka, H., Kusano, K. F., Ii, M., Luedemann, C., Curry, C., Eaton, E., Iwakura, A., Tsutsumi, Y., Hamada, H., Kishimoto, S., Thorne, T., Kishore, R., Losordo, D. W. (2006). Topical Sonic Hedgehog Gene Therapy Accelerates Wound Healing in Diabetes by Enhancing Endothelial Progenitor Cell-Mediated Microvascular Remodeling. Circulation 113: 2413-2424 [Abstract] [Full Text]
Yahata, Y., Shirakata, Y., Tokumaru, S., Yang, L., Dai, X., Tohyama, M., Tsuda, T., Sayama, K., Iwai, M., Horiuchi, M., Hashimoto, K. (2006). A Novel Function of Angiotensin II in Skin Wound Healing: INDUCTION OF FIBROBLAST AND KERATINOCYTE MIGRATION BY ANGIOTENSIN II VIA HEPARIN-BINDING EPIDERMAL GROWTH FACTOR (EGF)-LIKE GROWTH FACTOR-MEDIATED EGF RECEPTOR TRANSACTIVATION. J. Biol. Chem. 281: 13209-13216 [Abstract] [Full Text]
Ishida, Y., Kondo, T., Kimura, A., Matsushima, K., Mukaida, N. (2006). Absence of IL-1 Receptor Antagonist Impaired Wound Healing along with Aberrant NF-{kappa}B Activation and a Reciprocal Suppression of TGF-beta Signal Pathway. J. Immunol. 176: 5598-5606 [Abstract] [Full Text]
Enoch, S., Grey, J. E, Harding, K. G (2006). Recent advances and emerging treatments. BMJ 332: 962-965 [Full Text]
Meyer-ter-Vehn, T., Gebhardt, S., Sebald, W., Buttmann, M., Grehn, F., Schlunck, G., Knaus, P. (2006). p38 Inhibitors Prevent TGF-{beta}-Induced Myofibroblast Transdifferentiation in Human Tenon Fibroblasts.. IOVS 47: 1500-1509 [Abstract] [Full Text]
Cheon, S. S., Wei, Q., Gurung, A., Youn, A., Bright, T., Poon, R., Whetstone, H., Guha, A., Alman, B. A. (2006). Beta-catenin regulates wound size and mediates the effect of TGF-beta in cutaneous healing. FASEB J. 20: 692-701 [Abstract] [Full Text]
Zarbin, M A (2006). Progressive RPE atrophy around disciform scars.. Br J Ophthalmol 90: 396-397 [Full Text]
Athanasopoulos, A. N., Economopoulou, M., Orlova, V. V., Sobke, A., Schneider, D., Weber, H., Augustin, H. G., Eming, S. A., Schubert, U., Linn, T., Nawroth, P. P., Hussain, M., Hammes, H.-P., Herrmann, M., Preissner, K. T., Chavakis, T. (2006). The extracellular adherence protein (Eap) of Staphylococcus aureus inhibits wound healing by interfering with host defense and repair mechanisms. Blood 107: 2720-2727 [Abstract] [Full Text]
Bandyopadhyay, B., Fan, J., Guan, S., Li, Y., Chen, M., Woodley, D. T., Li, W. (2006). A "traffic control" role for TGF{beta}3: orchestrating dermal and epidermal cell motility during wound healing. JCB 172: 1093-1105 [Abstract] [Full Text]
Sweitzer, S. M., Fann, S. A., Borg, T. K., Baynes, J. W., Yost, M. J. (2006). What is the future of diabetic wound care?. The Diabetes Educator 32: 197-210 [Abstract] [Full Text]
Park, K.-S., Wells, J. M., Zorn, A. M., Wert, S. E., Laubach, V. E., Fernandez, L. G., Whitsett, J. A. (2006). Transdifferentiation of Ciliated Cells during Repair of the Respiratory Epithelium. Am. J. Respir. Cell Mol. Bio. 34: 151-157 [Abstract] [Full Text]
Pullar, C. E., Grahn, J. C., Liu, W., Isseroff, R. R. (2006). {beta}2-Adrenergic receptor activation delays wound healing. FASEB J. 20: 76-86 [Abstract] [Full Text]
Godbout, C., Frenette, J. (2006). Periodic Direct Current Does Not Promote Wound Closure in an In Vitro Dynamic Model of Cell Migration. ptjournal 86: 50-59 [Abstract] [Full Text]

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