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Previous Volume 341:755-757 September 2, 1999 Number 10 Next

	Since this article has no abstract, we have provided an extract of the first 100 words of the full text and any section headings.

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Hereditary hemochromatosis is the most common genetic disorder in whites. The prevalence of this condition (i.e., of homozygosity for the faulty gene) in the white population is approximately 1 in 250.^1,2 The localization of the gene to the short arm of chromosome 6 (6p) by means of linkage studies confirmed the genetic nature of the disorder, but the actual gene remained elusive until the advent of positional cloning. The faulty hemochromatosis gene (HFE ) was discovered in 1996,³ and since then multiple reports have confirmed that a point mutation in HFE (the substitution of tyrosine for cysteine at position . . . [Full Text of this Article]

References

This article has been cited by other articles:

• Schmitt, B., Golub, R. M., Green, R. (2005). Screening Primary Care Patients for Hereditary Hemochromatosis with Transferrin Saturation and Serum Ferritin Level: Systematic Review for the American College of Physicians. ANN INTERN MED 143: 522-536 [Abstract] [Full Text]  
• Bathum, L., Christiansen, L., Nybo, H., Ranberg, K. A., Gaist, D., Jeune, B., Petersen, N. E., Vaupel, J., Christensen, K. (2001). Association of Mutations in the Hemochromatosis Gene With Shorter Life Expectancy. Arch Intern Med 161: 2441-2444 [Abstract] [Full Text]  
• Sham, R. L., Raubertas, R. F., Braggins, C., Cappuccio, J., Gallagher, M., Phatak, P. D. (2000). Asymptomatic hemochromatosis subjects: genotypic and phenotypic profiles. Blood 96: 3707-3711 [Abstract] [Full Text]