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Previous Volume 341:1076-1078 September 30, 1999 Number 14 Next

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Muscle pain and fatigue affect nearly half of patients who seek medical care.¹ One of the paradoxes of medicine is that patients with these symptoms seldom have a recognizable disorder of muscle that can be identified by objective diagnostic tests such as muscle biopsy, electrophysiology, or imaging.¹ The inability to arrive at a specific diagnosis is frustrating to both patients and physicians. In this issue of the Journal, Andreu et al.² describe five patients with severe limitation of exercise due to muscle fatigability, as well as muscle pain and cramps. These patients were part of a larger group of patients . . . [Full Text of this Article]

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