In the not-so-distant past, type 2 diabetes mellitus was thoughtto be a relatively benign condition, at least in the elderly,with relatively little effect on life expectancy or renal function.1It has now become obvious that type 2 diabetes must be takenevery bit as seriously as type 1 diabetes, in part because ofits renal complications.2 However, some recent and encouragingevidence indicates that diabetic nephropathy and deteriorationof renal function are to a certain extent preventable.
Epidemiology
According to the reports of the U.S. Renal Data System,3,4 inthe past two decades there has been a continual increase . . . [Full Text of this Article]
Renal Lesions
Genetic Basis
Risk Factors
Glycemia
Smoking
Protein Intake
Blood Pressure
Renal Failure
Source Information
From the Department of Internal Medicine, Renal Unit, Ruperto Carola University, Bergheimer Str. 56a, D-69115 Heidelberg, Germany, where reprint requests should be addressed to Dr. Ritz.
Zdychova, J., Kazdova, L., Pelikanova, T., Lindsley, J. N., Anderson, S., Komers, R.
(2008). Renal Activity of Akt Kinase in Obese Zucker Rats. Exp. Biol. Med.
233: 1231-1241
[Abstract][Full Text]
Izuhara, Y., Sada, T., Yanagisawa, H., Koike, H., Ohtomo, S., Dan, T., Ito, S., Nangaku, M., van Ypersele de Strihou, C., Miyata, T.
(2008). A Novel Sartan Derivative With Very Low Angiotensin II Type 1 Receptor Affinity Protects the Kidney in Type 2 Diabetic Rats. Arterioscler. Thromb. Vasc. Bio.
28: 1767-1773
[Abstract][Full Text]
Omori, K., Ohira, T., Uchida, Y., Ayilavarapu, S., Batista, E. L. Jr., Yagi, M., Iwata, T., Liu, H., Hasturk, H., Kantarci, A., Van Dyke, T. E.
(2008). Priming of neutrophil oxidative burst in diabetes requires preassembly of the NADPH oxidase. J. Leukoc. Biol.
84: 292-301
[Abstract][Full Text]
White, S. L., McGeechan, K., Jones, M., Cass, A., Chadban, S. J., Polkinghorne, K. R., Perkovic, V., Roderick, P. J.
(2008). Socioeconomic Disadvantage and Kidney Disease in the United States, Australia, and Thailand. Am. J. Public Health
98: 1306-1313
[Abstract][Full Text]
Kattla, J. J., Carew, R. M., Heljic, M., Godson, C., Brazil, D. P.
(2008). Protein kinase B/Akt activity is involved in renal TGF-{beta}1-driven epithelial-mesenchymal transition in vitro and in vivo. Am. J. Physiol. Renal Physiol.
295: F215-F225
[Abstract][Full Text]
Obermayr, R. P., Temml, C., Knechtelsdorfer, M., Gutjahr, G., Kletzmayr, J., Heiss, S., Ponholzer, A., Madersbacher, S., Oberbauer, R., Klauser-Braun, R.
(2008). Predictors of new-onset decline in kidney function in a general middle-european population. Nephrol Dial Transplant
23: 1265-1273
[Abstract][Full Text]
Kelly, C. J., Booth, G.
(2008). Pharmacist-led structured care for patients with diabetic nephropathy. British Journal of Diabetes & Vascular Disease
8: 86-88
[Abstract]
Ohno, T., Takamoto, S., Motomura, N.
(2008). Diabetic Retinopathy and Coronary Artery Disease From the Cardiac Surgeon's Perspective. Ann. Thorac. Surg.
85: 681-689
[Abstract][Full Text]
Sloan, F. A., Bethel, M. A., Ruiz, D. Jr, Shea, A. H., Feinglos, M. N.
(2008). The Growing Burden of Diabetes Mellitus in the US Elderly Population. Arch Intern Med
168: 192-199
[Abstract][Full Text]
Yee, J.
(2008). Diabetic Kidney Disease: Chronic Kidney Disease and Diabetes. Diabetes Spectr.
21: 8-10
[Full Text]
Odden, M. C., Scherzer, R., Bacchetti, P., Szczech, L. A., Sidney, S., Grunfeld, C., Shlipak, M. G.
(2007). Cystatin C Level as a Marker of Kidney Function in Human Immunodeficiency Virus Infection: The FRAM Study. Arch Intern Med
167: 2213-2219
[Abstract][Full Text]
Tentolouris, N., Nzietchueng, R., Cattan, V., Poitevin, G., Lacolley, P., Papazafiropoulou, A., Perrea, D., Katsilambros, N., Benetos, A.
(2007). White Blood Cells Telomere Length Is Shorter in Males With Type 2 Diabetes and Microalbuminuria. Diabetes Care
30: 2909-2915
[Abstract][Full Text]
Griffin, K. A., Abu-Naser, M., Abu-Amarah, I., Picken, M., Williamson, G. A., Bidani, A. K.
(2007). Dynamic blood pressure load and nephropathy in the ZSF1 (fa/facp) model of type 2 diabetes. Am. J. Physiol. Renal Physiol.
293: F1605-F1613
[Abstract][Full Text]
Bavbek, N., Kargili, A., Kaftan, O., Karakurt, F., Kosar, A., Akcay, A.
(2007). Elevated Concentrations of Soluble Adhesion Molecules and Large Platelets in Diabetic Patients: Are They Markers of Vascular Disease and Diabetic Nephropathy?. CLIN APPL THROMB HEMOST
13: 391-397
[Abstract]
Maahs, D. M., Snively, B. M., Bell, R. A., Dolan, L., Hirsch, I., Imperatore, G., Linder, B., Marcovina, S. M., Mayer-Davis, E. J., Pettitt, D. J., Rodriguez, B. L., Dabelea, D.
(2007). Higher Prevalence of Elevated Albumin Excretion in Youth With Type 2 Than Type 1 Diabetes: The SEARCH for Diabetes in Youth Study. Diabetes Care
30: 2593-2598
[Abstract][Full Text]
Elsayed, E. F., Tighiouart, H., Griffith, J., Kurth, T., Levey, A. S., Salem, D., Sarnak, M. J., Weiner, D. E.
(2007). Cardiovascular Disease and Subsequent Kidney Disease. Arch Intern Med
167: 1130-1136
[Abstract][Full Text]
Rosenthal, T., Rosenmann, E., Tomassoni, D., Amenta, F.
(2007). Effect of Lercanidipine on Kidney Microanatomy in Cohen-Rosenthal Diabetic Hypertensive Rats. J CARDIOVASC PHARMACOL THER
12: 145-152
[Abstract]
Holt, R. M., Schwartz, F. L., Shubrook, J. H.
(2007). Diabetes Care in Extended-Care Facilities: Appropriate intensity of care?. Diabetes Care
30: 1454-1458
[Abstract][Full Text]
Lin, H.-Y., Wang, C.-L., Hsiao, P.-J., Lu, Y.-C., Chen, S.-Y., Lin, K.-D., Hsin, S.-C., Hsieh, M.-C., Shin, S.-J.
(2007). SUMO4 M55V Variant Is Associated With Diabetic Nephropathy in Type 2 Diabetes. Diabetes
56: 1177-1180
[Abstract][Full Text]
Lee, S., Kim, W., Moon, S.-O., Sung, M. J., Kim, D. H., Kang, K. P., Jang, K. Y., Lee, S. Y., Park, B. H., Koh, G. Y., Park, S. K.
(2007). Renoprotective effect of COMP-angiopoietin-1 in db/db mice with type 2 diabetes. Nephrol Dial Transplant
22: 396-408
[Abstract][Full Text]
Hartner, A., Cordasic, N., Klanke, B., Wittmann, M., Veelken, R., Hilgers, K. F.
(2007). Renal injury in streptozotocin-diabetic Ren2-transgenic rats is mainly dependent on hypertension, not on diabetes. Am. J. Physiol. Renal Physiol.
292: F820-F827
[Abstract][Full Text]
Koopman, R. J., Mainous, A. G. III, Liszka, H. A., Colwell, J. A., Slate, E. H., Carnemolla, M. A., Everett, C. J.
(2006). Evidence of Nephropathy and Peripheral Neuropathy in US Adults With Undiagnosed Diabetes.. Ann Fam Med
4: 427-432
[Abstract][Full Text]
Mann, J. F. E., McClellan, W. M., Kunz, R., Ritz, E.
(2006). Progression of renal disease--can we forget about inhibition of the renin-angiotensin system?. Nephrol Dial Transplant
21: 2348-2351
[Full Text]
Retnakaran, R., Cull, C. A., Thorne, K. I., Adler, A. I., Holman, R. R., for the UKPDS Study Group,
(2006). Risk Factors for Renal Dysfunction in Type 2 Diabetes: U.K. Prospective Diabetes Study 74. Diabetes
55: 1832-1839
[Abstract][Full Text]
Moran, A., Palmas, W., Pickering, T. G., Schwartz, J. E., Field, L., Weinstock, R. S., Shea, S.
(2006). Office and Ambulatory Blood Pressure Are Independently Associated With Albuminuria in Older Subjects With Type 2 Diabetes. Hypertension
47: 955-961
[Abstract][Full Text]
Remuzzi, G., Macia, M., Ruggenenti, P.
(2006). Prevention and Treatment of Diabetic Renal Disease in Type 2 Diabetes: The BENEDICT Study. J. Am. Soc. Nephrol.
17: S90-S97
[Abstract][Full Text]
Asbun, J., Villarreal, F. J.
(2006). The Pathogenesis of Myocardial Fibrosis in the Setting of Diabetic Cardiomyopathy. J Am Coll Cardiol
47: 693-700
[Abstract][Full Text]
Inagi, R., Yamamoto, Y., Nangaku, M., Usuda, N., Okamato, H., Kurokawa, K., van Ypersele de Strihou, C., Yamamoto, H., Miyata, T.
(2006). A Severe Diabetic Nephropathy Model With Early Development of Nodule-Like Lesions Induced by Megsin Overexpression in RAGE/iNOS Transgenic Mice. Diabetes
55: 356-366
[Abstract][Full Text]
Nangaku, M., Izuhara, Y., Usuda, N., Inagi, R., Shibata, T., Sugiyama, S., Kurokawa, K., van Ypersele de Strihou, C., Miyata, T.
(2005). In a type 2 diabetic nephropathy rat model, the improvement of obesity by a low calorie diet reduces oxidative/carbonyl stress and prevents diabetic nephropathy. Nephrol Dial Transplant
20: 2661-2669
[Abstract][Full Text]
Izuhara, Y., Nangaku, M., Inagi, R., Tominaga, N., Aizawa, T., Kurokawa, K., van Ypersele de Strihou, C., Miyata, T.
(2005). Renoprotective Properties of Angiotensin Receptor Blockers beyond Blood Pressure Lowering. J. Am. Soc. Nephrol.
16: 3631-3641
[Abstract][Full Text]
Strippoli, G. F.M., Craig, M., Schena, F. P., Craig, J. C.
(2005). Antihypertensive Agents for Primary Prevention of Diabetic Nephropathy. J. Am. Soc. Nephrol.
16: 3081-3091
[Abstract][Full Text]
Song, K.-H., Ko, S. H., Kim, H.-W., Ahn, Y.-B., Lee, J.-M., Son, H.-S., Yoon, K.-H., Cha, B.-Y., Lee, K.-W., Son, H.-Y.
(2005). Prospective Study of Lipoprotein(a) as a Risk Factor for Deteriorating Renal Function in Type 2 Diabetic Patients With Overt Proteinuria. Diabetes Care
28: 1718-1723
[Abstract][Full Text]
Rigalleau, V., Lasseur, C., Perlemoine, C., Barthe, N., Raffaitin, C., Liu, C., Chauveau, P., Baillet-Blanco, L., Beauvieux, M.-C., Combe, C., Gin, H.
(2005). Estimation of Glomerular Filtration Rate in Diabetic Subjects: Cockcroft formula or Modification of Diet in Renal Disease study equation?. Diabetes Care
28: 838-843
[Abstract][Full Text]
Hilgers, K. F., Veelken, R.
(2005). Type 2 Diabetic Nephropathy: Never too Early to Treat?. J. Am. Soc. Nephrol.
16: 574-575
[Full Text]
Wasen, E., Isoaho, R., Mattila, K., Vahlberg, T., Kivela, S.-L., Irjala, K.
(2004). Renal Impairment Associated With Diabetes in the Elderly. Diabetes Care
27: 2648-2653
[Abstract][Full Text]
Zhao, H.-L., Tong, P. C.Y., Lai, F. M.M., Tomlinson, B., Chan, J. C.N.
(2004). Association of Glomerulopathy With the 5'-End Polymorphism of the Aldose Reductase Gene and Renal Insufficiency in Type 2 Diabetic Patients. Diabetes
53: 2984-2991
[Abstract][Full Text]
Strippoli, G. F M, Craig, M., Deeks, J. J, Schena, F. P., Craig, J. C
(2004). Effects of angiotensin converting enzyme inhibitors and angiotensin II receptor antagonists on mortality and renal outcomes in diabetic nephropathy: systematic review. BMJ
329: 828-
[Abstract][Full Text]
Meier, J. J., Nauck, M. A., Kranz, D., Holst, J. J., Deacon, C. F., Gaeckler, D., Schmidt, W. E., Gallwitz, B.
(2004). Secretion, Degradation, and Elimination of Glucagon-Like Peptide 1 and Gastric Inhibitory Polypeptide in Patients with Chronic Renal Insufficiency and Healthy Control Subjects. Diabetes
53: 654-662
[Abstract][Full Text]
Omori, K., Naruishi, K., Nishimura, F., Yamada-Naruishi, H., Takashiba, S.
(2004). High Glucose Enhances Interleukin-6-induced Vascular Endothelial Growth Factor 165 Expression via Activation of Gp130-mediated p44/42 MAPK-CCAAT/Enhancer Binding Protein Signaling in Gingival Fibroblasts. J. Biol. Chem.
279: 6643-6649
[Abstract][Full Text]
Wong, T. Y., Shankar, A., Klein, R., Klein, B. E.K.
(2004). Retinal Vessel Diameters and the Incidence of Gross Proteinuria and Renal Insufficiency in People With Type 1 Diabetes. Diabetes
53: 179-184
[Abstract][Full Text]
Gahagan, S., Silverstein, J., Committee on Native American Child Health, , Section on Endocrinology,
(2003). Prevention and Treatment of Type 2 Diabetes Mellitus in Children, With Special Emphasis on American Indian and Alaska Native Children. Pediatrics
112: e328-e328
[Abstract][Full Text]
Amann, B., Tinzmann, R., Angelkort, B.
(2003). ACE Inhibitors Improve Diabetic Nephropathy Through Suppression of Renal MCP-1. Diabetes Care
26: 2421-2425
[Abstract][Full Text]
Susztak, K., Sharma, K., Schiffer, M., McCue, P., Ciccone, E., Bottinger, E. P.
(2003). Genomic Strategies for Diabetic Nephropathy. J. Am. Soc. Nephrol.
14: S271-278
[Abstract][Full Text]
Kramer, H. J., Nguyen, Q. D., Curhan, G., Hsu, C.-y.
(2003). Renal Insufficiency in the Absence of Albuminuria and Retinopathy Among Adults With Type 2 Diabetes Mellitus. JAMA
289: 3273-3277
[Abstract][Full Text]
Konner, K., Nonnast-Daniel, B., Ritz, E.
(2003). The Arteriovenous Fistula. J. Am. Soc. Nephrol.
14: 1669-1680
[Full Text]
Ueda, H., Ishimura, E., Shoji, T., Emoto, M., Morioka, T., Matsumoto, N., Fukumoto, S., Miki, T., Inaba, M., Nishizawa, Y.
(2003). Factors Affecting Progression of Renal Failure in Patients With Type 2 Diabetes. Diabetes Care
26: 1530-1534
[Abstract][Full Text]
Nangaku, M., Miyata, T., Sada, T., Mizuno, M., Inagi, R., Ueda, Y., Ishikawa, N., Yuzawa, H., Koike, H., van Ypersele de Strihou, C., Kurokawa, K.
(2003). Anti-Hypertensive Agents Inhibit In Vivo the Formation of Advanced Glycation End Products and Improve Renal Damage in a Type 2 Diabetic Nephropathy Rat Model. J. Am. Soc. Nephrol.
14: 1212-1222
[Abstract][Full Text]
Mason, R. M., Wahab, N. A.
(2003). Extracellular Matrix Metabolism in Diabetic Nephropathy. J. Am. Soc. Nephrol.
14: 1358-1373
[Abstract][Full Text]
Mogensen, C. E., Viberti, G., Halimi, S., Ritz, E., Ruilope, L., Jermendy, G., Widimsky, J., Sareli, P., Taton, J., Rull, J., Erdogan, G., De Leeuw, P. W., Ribeiro, A., Sanchez, R., Mechmeche, R., Nolan, J., Sirotiakova, J., Hamani, A., Scheen, A., Hess, B., Luger, A., Thomas, S. M.
(2003). Effect of Low-Dose Perindopril/Indapamide on Albuminuria in Diabetes: Preterax in Albuminuria Regression: PREMIER. Hypertension
41: 1063-1071
[Abstract][Full Text]
Sheetz, M. J., King, G. L.
(2002). Molecular Understanding of Hyperglycemia's Adverse Effects for Diabetic Complications. JAMA
288: 2579-2588
[Abstract][Full Text]
Lurbe, E., Redon, J., Kesani, A., Pascual, J. M., Tacons, J., Alvarez, V., Batlle, D.
(2002). Increase in Nocturnal Blood Pressure and Progression to Microalbuminuria in Type 1 Diabetes. NEJM
347: 797-805
[Abstract][Full Text]
Makino, H., Tanaka, I., Mukoyama, M., Sugawara, A., Mori, K., Muro, S., Suganami, T., Yahata, K., Ishibashi, R., Ohuchida, S., Maruyama, T., Narumiya, S., Nakao, K.
(2002). Prevention of Diabetic Nephropathy in Rats by Prostaglandin E Receptor EP1-Selective Antagonist. J. Am. Soc. Nephrol.
13: 1757-1765
[Abstract][Full Text]
Gambaro, G., Kinalska, I., Oksa, A., Pont'uch, P., Hertlova, M., Olsovsky, J., Manitius, J., Fedele, D., Czekalski, S., Perusicova, J., Skrha, J., Taton, J., Grzeszczak, W., Crepaldi, G.
(2002). Oral Sulodexide Reduces Albuminuria in Microalbuminuric and Macroalbuminuric Type 1 and Type 2 Diabetic Patients: The Di.N.A.S. Randomized Trial. J. Am. Soc. Nephrol.
13: 1615-1625
[Abstract][Full Text]
Remuzzi, G., Schieppati, A., Ruggenenti, P.
(2002). Nephropathy in Patients with Type 2 Diabetes. NEJM
346: 1145-1151
[Full Text]
Hilgers, K. F., Mann, J. F. E.
(2002). ACE Inhibitors versus AT1 Receptor Antagonists in Patients with Chronic Renal Disease. J. Am. Soc. Nephrol.
13: 1100-1108
[Full Text]
Bilous, R. W
(2002). Angiotensin II receptor blockade and type 2 diabetic nephropathy. British Journal of Diabetes & Vascular Disease
2: 101-105
[Abstract]
Hostetter, T. H.
(2001). Prevention of End-Stage Renal Disease Due to Type 2 Diabetes. NEJM
345: 910-912
[Full Text]
Tabaei, B. P., Al-Kassab, A. S., Ilag, L. L., Zawacki, C. M., Herman, W. H.
(2001). Does Microalbuminuria Predict Diabetic Nephropathy?. Diabetes Care
24: 1560-1566
[Abstract][Full Text]
Cooper, D. S., DeAngelis, C. D.
(2001). Diabetes Mellitus--A Call for Papers. JAMA
286: 968-969
[Full Text]
Schindler, R., Radke, C., Paul, K., Frei, U.
(2001). Renal problems after lung transplantation of cystic fibrosis patients. Nephrol Dial Transplant
16: 1324-1328
[Full Text]
Geerlings, S. E., Stolk, R. P., Camps, M. J. L., Netten, P. M., Collet, J. T., Schneeberger, P. M., Hoepelman, A. I. M.
(2001). Consequences of Asymptomatic Bacteriuria in Women With Diabetes Mellitus. Arch Intern Med
161: 1421-1427
[Abstract][Full Text]
STROJEK, K., GRZESZCZAK, W., GÓRSKA, J., LESCHINGER, M. I., RITZ, E.
(2001). Lowering of Microalbuminuria in Diabetic Patients by a Sympathicoplegic Agent: Novel Approach to Prevent Progression of Diabetic Nephropathy?. J. Am. Soc. Nephrol.
12: 602-605
[Abstract][Full Text]
Olefsky, J. M.
(2001). Prospects for Research in Diabetes Mellitus. JAMA
285: 628-632
[Abstract][Full Text]
Cheng, Z. J., Vaskonen, T., Tikkanen, I., Nurminen, K., Ruskoaho, H., Vapaatalo, H., Muller, D., Park, J.-K., Luft, F. C., Mervaala, E. M. A.
(2001). Endothelial Dysfunction and Salt-Sensitive Hypertension in Spontaneously Diabetic Goto-Kakizaki Rats. Hypertension
37: 433-439
[Abstract][Full Text]
Ruggenenti, P., Remuzzi, G.
(2000). Nephropathy of type 1 and type 2 diabetes: diverse pathophysiology, same treatment?. Nephrol Dial Transplant
15: 1900-1902
[Full Text]
Siffert, W.
(2000). G protein {beta}3 subunit 825T allele, hypertension, obesity, and diabetic nephropathy. Nephrol Dial Transplant
15: 1298-1306
[Abstract][Full Text]
Weinberg, M. S, Weinberg, A. J, Zappe, D. H
(2000). Effectively targetting the renin-angiotensin-aldosterone system in cardiovascular and renal disease: rationale for using angiotensin II receptor blockers in combination with angiotensin-converting enzyme inhibitors. Journal of Renin-Angiotensin-Aldosterone System
1: 217-233
Mora, C., Garcia, J., Navarro, J. F., Vandor, T., Grace, D. M., Ritz, E., Orth, S.
(2000). Nephropathy in Type 2 Diabetes. NEJM
342: 441-442
[Full Text]