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Previous Volume 341:1229-1231 October 14, 1999 Number 16 Next

	Since this article has no abstract, we have provided an extract of the first 100 words of the full text and any section headings.

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Modern perinatal care, including careful fetal surveillance, antenatal administration of glucocorticoids, surfactant therapy, and ventilatory assistance, has improved survival rates for infants with very low birth weights (less than 1500 g).¹ There has, however, been no improvement in the neurodevelopmental outcomes of such infants: 20 to 40 percent have handicaps, especially the smallest (those weighing less than 750 g) and least mature (those born before 25 weeks of gestation).^2,3 Periventricular leukomalacia is included in the spectrum of recently designated white-matter disorders⁴ and is a major risk factor for cerebral palsy and other handicaps, especially in premature infants.

Periventricular leukomalacia refers . . . [Full Text of this Article]

References

This article has been cited by other articles:

• Stoll, B. J., Hansen, N. I., Adams-Chapman, I., Fanaroff, A. A., Hintz, S. R., Vohr, B., Higgins, R. D., for the National Institute of Child Health and Hum, (2004). Neurodevelopmental and Growth Impairment Among Extremely Low-Birth-Weight Infants With Neonatal Infection. JAMA 292: 2357-2365 [Abstract] [Full Text]  
• Kadhim, H., Tabarki, B., Verellen, G., De Prez, C., Rona, A.-M., Sebire, G. (2001). Inflammatory cytokines in the pathogenesis of periventricular leukomalacia. Neurology 56: 1278-1284 [Abstract] [Full Text]