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Correction to Vartanian and de la Monte, N Engl J Med 340(2):127-135 January 14, 1999.

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Volume 341:1314-1316 October 21, 1999 Number 17
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Case 1-1999: Acute Hemorrhagic Leukoencephalitis

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 by Vartanian, T. K.
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 by Vartanian, T. K.
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To the Editor: The evaluation of a 53-year-old man with fever and rapid neurologic deterioration in the January 14 Case Record1 is a good example of the use of laboratory tests for the diagnosis of bacterial meningitis that have little or no clinical utility. A lumbar puncture was performed, tests for bacterial antigens (Haemophilus influenzae, Streptococcus pneumoniae, and Neisseria meningitidis) and syphilis were performed on cerebrospinal fluid, and cold agglutinins were tested in serum.

Although their use was in favor during the 1980s, bacterial-antigen tests have been shown to be insensitive and nonspecific and to have little, if . . . [Full Text of this Article]

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