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Previous Volume 341:1475-1476 November 4, 1999 Number 19 Next

	Since this article has no abstract, we have provided an extract of the first 100 words of the full text and any section headings.

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To the Editor: Voltz et al. (June 10 issue)¹ report finding antibodies against a new neuronal antigen (Ma2) in paraneoplastic limbic and brain-stem encephalitis associated with testicular cancer. They suggest that "patients with symptoms of paraneoplastic limbic or brain-stem encephalitis, particularly if they are young men, should be examined for serum antibodies against Ma2. Detection of these antibodies supports the diagnosis of a paraneoplastic syndrome and guides the search for the tumor to the testis." We disagree.

The authors cite epidemiologic evidence that 80 percent of patients with paraneoplastic limbic encephalitis have small-cell lung cancer. In the remaining 20 percent, . . . [Full Text of this Article]

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