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Correspondence
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Volume 341:127-128 July 8, 1999 Number 2
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Reappearance of Hepatitis B 10 Years after Kidney Transplantation

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To the Editor: In patients infected with hepatitis B virus (HBV), the disappearance of circulating antigens and the development of antibodies to these antigens have traditionally meant that the infection has cleared. Subsequent immunity has been believed to be lifelong.

We describe the reappearance of HBV infection 10 years after renal transplantation in a 42-year-old immigrant from Singapore who was believed to be immune to the virus. Before and after transplantation, she was consistently negative for hepatitis B surface antigen (HBsAg), positive for antibodies to HBsAg (anti-HBs) and core antigen (anti-HBc), and negative for HBV DNA on polymerase-chain-reaction (PCR) testing.1 . . . [Full Text of this Article]

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