Cellular Origin of Human B-Cell Lymphomas

doi:10.1056/NEJM199911113412007

Volume 341:1520-1529		November 11, 1999		Number 20

Cellular Origin of Human B-Cell Lymphomas

Ralf Küppers, Ph.D., Ulf Klein, Ph.D., Martin-Leo Hansmann, M.D., and Klaus Rajewsky, M.D.

Since this article has no abstract, we have provided an extract of the first 100 words of the full text and any section headings.

Full Text

PDF

Purchase this article

Add to Personal Archive

Add to Citation Manager

Notify a Friend

E-mail When Cited

PubMed Citation

The origin of human lymphomas has been studied by various approaches,including histology and immunophenotyping. In some types oflymphoma these studies suggested the cellular origin, but inmany instances the origin could not be identified. When somaticmutations of the genes for the variable region of the B-lymphocyteantigen receptor proved to be a hallmark of germinal-centerB cells and their descendants, sequence analysis of the variable-regiongenes of B-cell lymphomas offered a molecular approach to studyingthe origin of the tumors. Before discussing the results of thesestudies, we outline the human peripheral B-cell repertoire andits generation.

The Human Peripheral B-Cell Repertoire and Its Generation

Antibody Specificity and Selection of B Cells

. . . [Full Text of this Article]

Genetic Changes in B Cells within Germinal Centers

The Peripheral B-Cell Repertoire in Humans

Precursors of Human B-Cell Lymphomas

Non-Hodgkin's Lymphomas

Hodgkin's Disease

The Role of Germinal Centers in the Pathogenesis of B-Cell Tumors

Transforming Events as Byproducts of B-Cell Differentiation in the Germinal Center

Dependence of B-Cell Lymphomas on the Expression of Antigen Receptors and the Microenvironment

The Diversity of Human B-Cell Lymphomas

Conclusions

Source Information

From the Institute for Genetics (R.K., U.K., K.R.) and the Department of Internal Medicine (R.K.), University of Cologne, Cologne; and the Department of Pathology, University of Frankfurt, Frankfurt (M.-L.H.) — both in Germany.

Address reprint requests to Dr. Küppers at the University of Cologne, Department of Internal Medicine, LFI E4 R706, Joseph-Stelzmannstr. 9, 50931 Cologne, Germany, or at rkuppers@mac.genetik.uni-koeln.de.

References

This article has been cited by other articles:

Dussault, N., Ducas, E., Racine, C., Jacques, A., Pare, I., Cote, S., Neron, S. (2008). Immunomodulation of human B cells following treatment with intravenous immunoglobulins involves increased phosphorylation of extracellular signal-regulated kinases 1 and 2. Int Immunol 20: 1369-1379 [Abstract] [Full Text]
Scholz, J. L., Crowley, J. E., Tomayko, M. M., Steinel, N., O'Neill, P. J., Quinn, W. J. III, Goenka, R., Miller, J. P., Cho, Y. H., Long, V., Ward, C., Migone, T.-S., Shlomchik, M. J., Cancro, M. P. (2008). BLyS inhibition eliminates primary B cells but leaves natural and acquired humoral immunity intact. Proc. Natl. Acad. Sci. USA 105: 15517-15522 [Abstract] [Full Text]
Capello, D., Martini, M., Gloghini, A., Cerri, M., Rasi, S., Deambrogi, C., Rossi, D., Spina, M., Tirelli, U., Larocca, L. M., Carbone, A., Gaidano, G. (2008). Molecular analysis of immunoglobulin variable genes in human immunodeficiency virus-related non-Hodgkin's lymphoma reveals implications for disease pathogenesis and histogenesis. haematol 93: 1178-1185 [Abstract] [Full Text]
Quijano, S., Lopez, A., Rasillo, A., Barrena, S., Luz Sanchez, M., Flores, J., Fernandez, C., Sayagues, J. M., Osuna, C. S., Fernandez, N., Gonzalez, M., Giraldo, P., Giralt, M., Perez, M. C., Martin-Antoran, J. M., Gutierrez, O., Perdiguer, L., Diaz Mediavilla, J., Gonzalez Silva, M., Asensio del Rio, A., Cervero, C., Guerra, J. L., Butron, R., del Carmen Garcia, M., Almeida, J., Orfao, A. (2008). Association between the proliferative rate of neoplastic B cells, their maturation stage, and underlying cytogenetic abnormalities in B-cell chronic lymphoproliferative disorders: analysis of a series of 432 patients. Blood 111: 5130-5141 [Abstract] [Full Text]
Mendez, L. M., Polo, J. M., Yu, J. J., Krupski, M., Ding, B. B., Melnick, A., Ye, B. H. (2008). CtBP Is an Essential Corepressor for BCL6 Autoregulation. Mol. Cell. Biol. 28: 2175-2186 [Abstract] [Full Text]
Maskarinec, G., Erber, E., Gill, J., Cozen, W., Kolonel, L. N. (2008). Overweight and Obesity at Different Times in Life as Risk Factors for Non-Hodgkin's Lymphoma: The Multiethnic Cohort. Cancer Epidemiol. Biomarkers Prev. 17: 196-203 [Abstract] [Full Text]
Lin, P., Medeiros, L. J. (2007). High-grade B-cell lymphoma/leukemia associated with t(14;18) and 8q24/MYC rearrangement: a neoplasm of germinal center immunophenotype with poor prognosis. haematol 92: 1297-1301 [Full Text]
Kuraishy, A. I., French, S. W., Sherman, M., Herling, M., Jones, D., Wall, R., Teitell, M. A. (2007). TORC2 regulates germinal center repression of the TCL1 oncoprotein to promote B cell development and inhibit transformation. Proc. Natl. Acad. Sci. USA 104: 10175-10180 [Abstract] [Full Text]
Volkheimer, A. D., Weinberg, J. B., Beasley, B. E., Whitesides, J. F., Gockerman, J. P., Moore, J. O., Kelsoe, G., Goodman, B. K., Levesque, M. C. (2007). Progressive immunoglobulin gene mutations in chronic lymphocytic leukemia: evidence for antigen-driven intraclonal diversification. Blood 109: 1559-1567 [Abstract] [Full Text]
van Galen, J. C, Muris, J. J F, Oudejans, J. J, Vos, W., Giroth, C. P E, Ossenkoppele, G. J, Otte, A. P, Raaphorst, F. M, Meijer, C. J L M (2007). Expression of the polycomb-group gene BMI1 is related to an unfavourable prognosis in primary nodal DLBCL. J. Clin. Pathol. 60: 167-172 [Abstract] [Full Text]
Shipp, M. A. (2007). Molecular Signatures Define New Rational Treatment Targets in Large B-Cell Lymphomas. ASH Education Book 2007: 265-269 [Abstract] [Full Text]
Venugopal, P., Gregory, S. A. (2007). Lymphoproliferative disorders. ASH-SAP 2007: 265-297 [Full Text]
Chng, W. J., Schop, R. F., Price-Troska, T., Ghobrial, I., Kay, N., Jelinek, D. F., Gertz, M. A., Dispenzieri, A., Lacy, M., Kyle, R. A., Greipp, P. R., Tschumper, R. C., Fonseca, R., Bergsagel, P. L. (2006). Gene-expression profiling of Waldenstrom macroglobulinemia reveals a phenotype more similar to chronic lymphocytic leukemia than multiple myeloma. Blood 108: 2755-2763 [Abstract] [Full Text]
Fecteau, J. F., Cote, G., Neron, S. (2006). A New Memory CD27-IgG+ B Cell Population in Peripheral Blood Expressing VH Genes with Low Frequency of Somatic Mutation. J. Immunol. 177: 3728-3736 [Abstract] [Full Text]
Renne, C., Martin-Subero, J. I., Eickernjager, M., Hansmann, M.-L., Kuppers, R., Siebert, R., Brauninger, A. (2006). Aberrant Expression of ID2, a Suppressor of B-Cell-Specific Gene Expression, in Hodgkin's Lymphoma. Am. J. Pathol. 169: 655-664 [Abstract] [Full Text]
Schenten, D., Egert, A., Pasparakis, M., Rajewsky, K. (2006). M17, a gene specific for germinal center (GC) B cells and a prognostic marker for GC B-cell lymphomas, is dispensable for the GC reaction in mice. Blood 107: 4849-4856 [Abstract] [Full Text]
Takahashi, H., Feuerhake, F., Kutok, J. L., Monti, S., Dal Cin, P., Neuberg, D., Aster, J. C., Shipp, M. A. (2006). FAS Death Domain Deletions and Cellular FADD-like Interleukin 1{beta} Converting Enzyme Inhibitory Protein (Long) Overexpression: Alternative Mechanisms for Deregulating the Extrinsic Apoptotic Pathway in Diffuse Large B-Cell Lymphoma Subtypes.. Clin. Cancer Res. 12: 3265-3271 [Abstract] [Full Text]
De Re, V., De Vita, S., Sansonno, D., Gasparotto, D., Simula, M. P., Tucci, F. A., Marzotto, A., Fabris, M., Gloghini, A., Carbone, A., Dammacco, F., Boiocchi, M. (2006). Type II mixed cryoglobulinaemia as an oligo rather than a mono B-cell disorder: evidence from GeneScan and MALDI-TOF analyses. Rheumatology (Oxford) 45: 685-693 [Abstract] [Full Text]
Suarez, F., Lortholary, O., Hermine, O., Lecuit, M. (2006). Infection-associated lymphomas derived from marginal zone B cells: a model of antigen-driven lymphoproliferation. Blood 107: 3034-3044 [Abstract] [Full Text]
Tjin, E. P. M., Groen, R. W. J., Vogelzang, I., Derksen, P. W. B., Klok, M. D., Meijer, H. P., van Eeden, S., Pals, S. T., Spaargaren, M. (2006). Functional analysis of HGF/MET signaling and aberrant HGF-activator expression in diffuse large B-cell lymphoma. Blood 107: 760-768 [Abstract] [Full Text]
Economopoulos, T., Papageorgiou, S., Rontogianni, D., Kaloutsi, V., Fountzilas, G., Tsatalas, C., Pavlidis, N., Pectasides, D., Papageorgiou, E., Dimopoulos, M. (2005). Multifocal Extranodal Non-Hodgkin Lymphoma: A Clinicopathologic Study of 37 Cases in Greece, a Hellenic Cooperative Oncology Group Study. The Oncologist 10: 734-738 [Abstract] [Full Text]
Kodama, K., Massone, C., Chott, A., Metze, D., Kerl, H., Cerroni, L. (2005). Primary cutaneous large B-cell lymphomas: clinicopathologic features, classification, and prognostic factors in a large series of patients. Blood 106: 2491-2497 [Abstract] [Full Text]
Abramson, J. S., Shipp, M. A. (2005). Advances in the biology and therapy of diffuse large B-cell lymphoma: moving toward a molecularly targeted approach. Blood 106: 1164-1174 [Abstract] [Full Text]
Feuerhake, F., Kutok, J. L., Monti, S., Chen, W., LaCasce, A. S., Cattoretti, G., Kurtin, P., Pinkus, G. S., de Leval, L., Harris, N. L., Savage, K. J., Neuberg, D., Habermann, T. M., Dalla-Favera, R., Golub, T. R., Aster, J. C., Shipp, M. A. (2005). NF{kappa}B activity, function, and target-gene signatures in primary mediastinal large B-cell lymphoma and diffuse large B-cell lymphoma subtypes. Blood 106: 1392-1399 [Abstract] [Full Text]
Feldhahn, N., Klein, F., Mooster, J. L., Hadweh, P., Sprangers, M., Wartenberg, M., Bekhite, M. M., Hofmann, W.-K., Herzog, S., Jumaa, H., Rowley, J. D., Muschen, M. (2005). Mimicry of a constitutively active pre-B cell receptor in acute lymphoblastic leukemia cells. JEM 201: 1837-1852 [Abstract] [Full Text]
Kienle, D. L., Korz, C., Hosch, B., Benner, A., Mertens, D., Habermann, A., Krober, A., Jager, U., Lichter, P., Dohner, H., Stilgenbauer, S. (2005). Evidence for Distinct Pathomechanisms in Genetic Subgroups of Chronic Lymphocytic Leukemia Revealed by Quantitative Expression Analysis of Cell Cycle, Activation, and Apoptosis-Associated Genes. JCO 23: 3780-3792 [Abstract] [Full Text]
Muris, J. J. F., Cillessen, S. A. G. M., Vos, W., van Houdt, I. S., Kummer, J. A., van Krieken, J. H. J. M., Jiwa, N. M., Jansen, P. M., Kluin-Nelemans, H. C., Ossenkoppele, G. J., Gundy, C., Meijer, C. J. L. M., Oudejans, J. J. (2005). Immunohistochemical profiling of caspase signaling pathways predicts clinical response to chemotherapy in primary nodal diffuse large B-cell lymphomas. Blood 105: 2916-2923 [Abstract] [Full Text]
Monti, S., Savage, K. J., Kutok, J. L., Feuerhake, F., Kurtin, P., Mihm, M., Wu, B., Pasqualucci, L., Neuberg, D., Aguiar, R. C. T., Cin, P. D., Ladd, C., Pinkus, G. S., Salles, G., Harris, N. L., Dalla-Favera, R., Habermann, T. M., Aster, J. C., Golub, T. R., Shipp, M. A. (2005). Molecular profiling of diffuse large B-cell lymphoma identifies robust subtypes including one characterized by host inflammatory response. Blood 105: 1851-1861 [Abstract] [Full Text]
Atayar, C., Poppema, S., Blokzijl, T., Harms, G., Boot, M., van den Berg, A. (2005). Expression of the T-Cell Transcription Factors, GATA-3 and T-bet, in the Neoplastic Cells of Hodgkin Lymphomas. Am. J. Pathol. 166: 127-134 [Abstract] [Full Text]
Kuehl, W. M., Bergsagel, P. L. (2005). Early Genetic Events Provide the Basis for a Clinical Classification of Multiple Myeloma. ASH Education Book 2005: 346-352 [Abstract] [Full Text]
Tobin, G., Thunberg, U., Karlsson, K., Murray, F., Laurell, A., Willander, K., Enblad, G., Merup, M., Vilpo, J., Juliusson, G., Sundstrom, C., Soderberg, O., Roos, G., Rosenquist, R. (2004). Subsets with restricted immunoglobulin gene rearrangement features indicate a role for antigen selection in the development of chronic lymphocytic leukemia. Blood 104: 2879-2885 [Abstract] [Full Text]
Li, L., Yoon, S.-O., Fu, D.-D., Zhang, X., Choi, Y. S. (2004). Novel follicular dendritic cell molecule, 8D6, collaborates with CD44 in supporting lymphomagenesis by a Burkitt lymphoma cell line, L3055. Blood 104: 815-821 [Abstract] [Full Text]
Guiter, C., Dusanter-Fourt, I., Copie-Bergman, C., Boulland, M.-L., le Gouvello, S., Gaulard, P., Leroy, K., Castellano, F. (2004). Constitutive STAT6 activation in primary mediastinal large B-cell lymphoma. Blood 104: 543-549 [Abstract] [Full Text]
Gemmati, D., Ongaro, A., Scapoli, G. L., Della Porta, M., Tognazzo, S., Serino, M. L., Di Bona, E., Rodeghiero, F., Gilli, G., Reverberi, R., Caruso, A., Pasello, M., Pellati, A., De Mattei, M. (2004). Common Gene Polymorphisms in the Metabolic Folate and Methylation Pathway and the Risk of Acute Lymphoblastic Leukemia and non-Hodgkin's Lymphoma in Adults. Cancer Epidemiol. Biomarkers Prev. 13: 787-794 [Abstract] [Full Text]
Zompi, S., Couderc, L.-J., Cadranel, J., Antoine, M., Epardeau, B., Fleury-Feith, J., Popa, N., Santoli, F., Farcet, J.-P., Delfau-Larue, M.-H. (2004). Clonality analysis of alveolar B lymphocytes contributes to the diagnostic strategy in clinical suspicion of pulmonary lymphoma. Blood 103: 3208-3215 [Abstract] [Full Text]
Teitell, M. A. (2004). T cells in mouse follicular lymphoma. Blood 103: 1981-1982 [Full Text]
Matsui, W., Huff, C. A., Wang, Q., Malehorn, M. T., Barber, J., Tanhehco, Y., Smith, B. D., Civin, C. I., Jones, R. J. (2004). Characterization of clonogenic multiple myeloma cells. Blood 103: 2332-2336 [Abstract] [Full Text]
He, B., Chadburn, A., Jou, E., Schattner, E. J., Knowles, D. M., Cerutti, A. (2004). Lymphoma B Cells Evade Apoptosis through the TNF Family Members BAFF/BLyS and APRIL. J. Immunol. 172: 3268-3279 [Abstract] [Full Text]
Mouhamad, S., Besnault, L., Auffredou, M. T., Leprince, C., Bourgeade, M. F., Leca, G., Vazquez, A. (2004). B Cell Receptor-Mediated Apoptosis of Human Lymphocytes Is Associated with a New Regulatory Pathway of Bim Isoform Expression. J. Immunol. 172: 2084-2091 [Abstract] [Full Text]
Basso, K., Liso, A., Tiacci, E., Benedetti, R., Pulsoni, A., Foa, R., Di Raimondo, F., Ambrosetti, A., Califano, A., Klein, U., Favera, R. D., Falini, B. (2004). Gene Expression Profiling of Hairy Cell Leukemia Reveals a Phenotype Related to Memory B Cells with Altered Expression of Chemokine and Adhesion Receptors. JEM 199: 59-68 [Abstract] [Full Text]
Falini, B., Tiacci, E., Pucciarini, A., Bigerna, B., Kurth, J., Hatzivassiliou, G., Droetto, S., Galletti, B. V., Gambacorta, M., Orazi, A., Pasqualucci, L., Miller, I., Kuppers, R., Dalla-Favera, R., Cattoretti, G. (2003). Expression of the IRTA1 receptor identifies intraepithelial and subepithelial marginal zone B cells of the mucosa-associated lymphoid tissue (MALT). Blood 102: 3684-3692 [Abstract] [Full Text]
Capello, D., Cerri, M., Muti, G., Berra, E., Oreste, P., Deambrogi, C., Rossi, D., Dotti, G., Conconi, A., Vigano, M., Magrini, U., Ippoliti, G., Morra, E., Gloghini, A., Rambaldi, A., Paulli, M., Carbone, A., Gaidano, G. (2003). Molecular histogenesis of posttransplantation lymphoproliferative disorders. Blood 102: 3775-3785 [Abstract] [Full Text]
Fecteau, J. F., Neron, S. (2003). CD40 Stimulation of Human Peripheral B Lymphocytes: Distinct Response from Naive and Memory Cells. J. Immunol. 171: 4621-4629 [Abstract] [Full Text]
Marafioti, T., Jones, M., Facchetti, F., Diss, T. C., Du, M.-Q., Isaacson, P. G., Pozzobon, M., Pileri, S. A., Strickson, A. J., Tan, S.-Y., Watkins, F., Mason, D. Y. (2003). Phenotype and genotype of interfollicular large B cells, a subpopulation of lymphocytes often with dendritic morphology. Blood 102: 2868-2876 [Abstract] [Full Text]
Kienle, D., Krober, A., Katzenberger, T., Ott, G., Leupolt, E., Barth, T. F. E., Moller, P., Benner, A., Habermann, A., Muller-Hermelink, H. K., Bentz, M., Lichter, P., Dohner, H., Stilgenbauer, S. (2003). VH mutation status and VDJ rearrangement structure in mantle cell lymphoma: correlation with genomic aberrations, clinical characteristics, and outcome. Blood 102: 3003-3009 [Abstract] [Full Text]
Jenner, R. G., Maillard, K., Cattini, N., Weiss, R. A., Boshoff, C., Wooster, R., Kellam, P. (2003). Kaposi's sarcoma-associated herpesvirus-infected primary effusion lymphoma has a plasma cell gene expression profile. Proc. Natl. Acad. Sci. USA 100: 10399-10404 [Abstract] [Full Text]
Greil, R., Anether, G., Johrer, K., Tinhofer, I. (2003). Tracking death dealing by Fas and TRAIL in lymphatic neoplastic disorders: pathways, targets, and therapeutic tools. J. Leukoc. Biol. 74: 311-330 [Abstract] [Full Text]
Gaidano, G., Pasqualucci, L., Capello, D., Berra, E., Deambrogi, C., Rossi, D., Maria Larocca, L., Gloghini, A., Carbone, A., Dalla-Favera, R. (2003). Aberrant somatic hypermutation in multiple subtypes of AIDS-associated non-Hodgkin lymphoma. Blood 102: 1833-1841 [Abstract] [Full Text]
Ranger, A. M., Zha, J., Harada, H., Datta, S. R., Danial, N. N., Gilmore, A. P., Kutok, J. L., Le Beau, M. M., Greenberg, M. E., Korsmeyer, S. J. (2003). Bad-deficient mice develop diffuse large B cell lymphoma. Proc. Natl. Acad. Sci. USA 100: 9324-9329 [Abstract] [Full Text]
Bernasconi, N. L., Onai, N., Lanzavecchia, A. (2003). A role for Toll-like receptors in acquired immunity: up-regulation of TLR9 by BCR triggering in naive B cells and constitutive expression in memory B cells. Blood 101: 4500-4504 [Abstract] [Full Text]
Walsh, S. H., Thorselius, M., Johnson, A., Soderberg, O., Jerkeman, M., Bjorck, E., Eriksson, I., Thunberg, U., Landgren, O., Ehinger, M., Lofvenberg, E., Wallman, K., Enblad, G., Sander, B., Porwit-MacDonald, A., Dictor, M., Olofsson, T., Sundstrom, C., Roos, G., Rosenquist, R. (2003). Mutated VH genes and preferential VH3-21 use define new subsets of mantle cell lymphoma. Blood 101: 4047-4054 [Abstract] [Full Text]
Enzler, T., Gillessen, S., Manis, J. P., Ferguson, D., Fleming, J., Alt, F. W., Mihm, M., Dranoff, G. (2003). Deficiencies of GM-CSF and Interferon {gamma} Link Inflammation and Cancer. JEM 197: 1213-1219 [Abstract] [Full Text]
Kurth, J., Hansmann, M.-L., Rajewsky, K., Kuppers, R. (2003). Epstein-Barr virus-infected B cells expanding in germinal centers of infectious mononucleosis patients do not participate in the germinal center reaction. Proc. Natl. Acad. Sci. USA 100: 4730-4735 [Abstract] [Full Text]
Gordon, M. S., Kanegai, C. M., Doerr, J. R., Wall, R. (2003). Somatic hypermutation of the B cell receptor genes B29 (Igbeta , CD79b) and mb1 (Igalpha , CD79a). Proc. Natl. Acad. Sci. USA 100: 4126-4131 [Abstract] [Full Text]
Klein, U., Tu, Y., Stolovitzky, G. A., Keller, J. L., Haddad, J. Jr., Miljkovic, V., Cattoretti, G., Califano, A., Dalla-Favera, R. (2003). Transcriptional analysis of the B cell germinal center reaction. Proc. Natl. Acad. Sci. USA 100: 2639-2644 [Abstract] [Full Text]
Diehl, V. (2003). Advanced Hodgkin's Disease: ABVD Is Better, Yet Is Not Good Enough!. JCO 21: 583-585 [Full Text]
Ghia, P., Guida, G., Stella, S., Gottardi, D., Geuna, M., Strola, G., Scielzo, C., Caligaris-Cappio, F. (2003). The pattern of CD38 expression defines a distinct subset of chronic lymphocytic leukemia (CLL) patients at risk of disease progression. Blood 101: 1262-1269 [Abstract] [Full Text]
Tierens, A., Delabie, J., Malecka, A., Wang, J., Gruszka-Westwood, A., Catovsky, D., Matutes, E. (2003). Splenic Marginal Zone Lymphoma with Villous Lymphocytes Shows On-Going Immunoglobulin Gene Mutations. Am. J. Pathol. 162: 681-689 [Abstract] [Full Text]
Wang, Y.-H., Zhang, Z., Burrows, P. D., Kubagawa, H., Bridges, S. L. Jr, Findley, H. W., Cooper, M. D. (2003). V(D)J recombinatorial repertoire diversification during intraclonal pro-B to B-cell differentiation. Blood 101: 1030-1037 [Abstract] [Full Text]
Pileri, S. A., Gaidano, G., Zinzani, P. L., Falini, B., Gaulard, P., Zucca, E., Pieri, F., Berra, E., Sabattini, E., Ascani, S., Piccioli, M., Johnson, P. W. M., Giardini, R., Pescarmona, E., Novero, D., Piccaluga, P. P., Marafioti, T., Alonso, M. A., Cavalli, F. (2003). Primary Mediastinal B-Cell Lymphoma: High Frequency of BCL-6 Mutations and Consistent Expression of the Transcription Factors OCT-2, BOB.1, and PU.1 in the Absence of Immunoglobulins. Am. J. Pathol. 162: 243-253 [Abstract] [Full Text]
Bernasconi, N. L., Traggiai, E., Lanzavecchia, A. (2002). Maintenance of Serological Memory by Polyclonal Activation of Human Memory B Cells. Science 298: 2199-2202 [Abstract] [Full Text]
Krober, A., Seiler, T., Benner, A., Bullinger, L., Bruckle, E., Lichter, P., Dohner, H., Stilgenbauer, S. (2002). VH mutation status, CD38 expression level, genomic aberrations, and survival in chronic lymphocytic leukemia. Blood 100: 1410-1416 [Abstract] [Full Text]
Hermine, O., Lefrere, F., Bronowicki, J.-P., Mariette, X., Jondeau, K., Eclache-Saudreau, V., Delmas, B., Valensi, F., Cacoub, P., Brechot, C., Varet, B., Troussard, X. (2002). Regression of Splenic Lymphoma with Villous Lymphocytes after Treatment of Hepatitis C Virus Infection. NEJM 347: 89-94 [Abstract] [Full Text]
Bosshart, H., Ansell, S. M., Jelinek, D. F., Wettstein, P. J., Witzig, T. E. (2002). T Helper Cell Activation in B-Cell Lymphomas. JCO 20: 2904-2905 [Full Text]
Pileri, S A, Ascani, S, Leoncini, L, Sabattini, E, Zinzani, P L, Piccaluga, P P, Pileri, A Jr, Giunti, M, Falini, B, Bolis, G B, Stein, H (2002). Hodgkin's lymphoma: the pathologist's viewpoint. J. Clin. Pathol. 55: 162-176 [Abstract] [Full Text]
Algara, P., Mateo, M. S., Sanchez-Beato, M., Mollejo, M., Navas, I. C., Romero, L., Sole, F., Salido, M., Florensa, L., Martinez, P., Campo, E., Piris, M. A. (2002). Analysis of the IgVH somatic mutations in splenic marginal zone lymphoma defines a group of unmutated cases with frequent 7q deletion and adverse clinical course. Blood 99: 1299-1304 [Abstract] [Full Text]
Falini, B., Mason, D. Y. (2002). Proteins encoded by genes involved in chromosomal alterations in lymphoma and leukemia: clinical value of their detection by immunocytochemistry. Blood 99: 409-426 [Abstract] [Full Text]
Fenton, J. A. L., Vaandrager, J.-W., Aarts, W. M., Bende, R. J., Heering, K., van Dijk, M., Morgan, G., van Noesel, C. J. M., Schuuring, E., Kluin, P. M. (2002). Follicular lymphoma with a novel t(14;18) breakpoint involving the immunoglobulin heavy chain switch mu region indicates an origin from germinal center B cells. Blood 99: 716-718 [Abstract] [Full Text]
Klein, U., Tu, Y., Stolovitzky, G. A., Mattioli, M., Cattoretti, G., Husson, H., Freedman, A., Inghirami, G., Cro, L., Baldini, L., Neri, A., Califano, A., Dalla-Favera, R. (2001). Gene Expression Profiling of B Cell Chronic Lymphocytic Leukemia Reveals a Homogeneous Phenotype Related to Memory B Cells. JEM 194: 1625-1638 [Abstract] [Full Text]
Xu, Y, Wiernik, P H (2001). Systemic lupus erythematosus and B-cell hematologic neoplasm. Lupus 10: 841-850 [Abstract]
Leithauser, F., Bauerle, M., Huynh, M. Q., Moller, P. (2001). Isotype-switched immunoglobulin genes with a high load of somatic hypermutation and lack of ongoing mutational activity are prevalent in mediastinal B-cell lymphoma. Blood 98: 2762-2770 [Abstract] [Full Text]
Brauninger, A., Spieker, T., Willenbrock, K., Gaulard, P., Wacker, H.-H., Rajewsky, K., Hansmann, M.-L., Kuppers, R. (2001). Survival and Clonal Expansion of Mutating "Forbidden" (Immunoglobulin Receptor-deficient) Epstein-Barr Virus-infected B Cells in Angioimmunoblastic T Cell Lymphoma. JEM 194: 927-940 [Abstract] [Full Text]
Conconi, A., Bertoni, F., Pedrinis, E., Motta, T., Roggero, E., Luminari, S., Capella, C., Bonato, M., Cavalli, F., Zucca, E. (2001). Nodal marginal zone B-cell lymphomas may arise from different subsets of marginal zone B lymphocytes. Blood 98: 781-786 [Abstract] [Full Text]
Sei, S., O'Neill, D. P., Stewart, S. K., Yang, Q.-e., Kumagai, M., Boler, A. M., Adde, M. A., Zwerski, S. L., Wood, L. V., Venzon, D. J., Magrath, I. T. (2001). Increased Level of Stromal Cell-Derived Factor-1 mRNA in Peripheral Blood Mononuclear Cells from Children with AIDS-related Lymphoma. Cancer Res. 61: 5028-5037 [Abstract] [Full Text]
Marasca, R., Vaccari, P., Luppi, M., Zucchini, P., Castelli, I., Barozzi, P., Cuoghi, A., Torelli, G. (2001). Immunoglobulin Gene Mutations and Frequent Use of VH1-69 and VH4-34 Segments in Hepatitis C Virus-Positive and Hepatitis C Virus-Negative Nodal Marginal Zone B-Cell Lymphoma. Am. J. Pathol. 159: 253-261 [Abstract] [Full Text]
Wang, C.-X., Wadehra, M., Fisk, B. C., Goodglick, L., Braun, J. (2001). Epithelial membrane protein 2, a 4-transmembrane protein that suppresses B-cell lymphoma tumorigenicity. Blood 97: 3890-3895 [Abstract] [Full Text]
van Kemenade, F. J., Raaphorst, F. M., Blokzijl, T., Fieret, E., Hamer, K. M., Satijn, D. P. E., Otte, A. P., Meijer, C. J. L. M. (2001). Coexpression of BMI-1 and EZH2 polycomb-group proteins is associated with cycling cells and degree of malignancy in B-cell non-Hodgkin lymphoma. Blood 97: 3896-3901 [Abstract] [Full Text]
Theil, J., Laumen, H., Marafioti, T., Hummel, M., Lenz, G., Wirth, T., Stein, H. (2001). Defective octamer-dependent transcription is responsible for silenced immunoglobulin transcription in Reed-Sternberg cells. Blood 97: 3191-3196 [Abstract] [Full Text]
Matsuo, K., Suzuki, R., Hamajima, N., Ogura, M., Kagami, Y., Taji, H., Kondoh, E., Maeda, S., Asakura, S., Kaba, S., Nakamura, S., Seto, M., Morishima, Y., Tajima, K. (2001). Association between polymorphisms of folate- and methionine-metabolizing enzymes and susceptibility to malignant lymphoma. Blood 97: 3205-3209 [Abstract] [Full Text]
Du, M.-Q., Liu, H., Diss, T. C., Ye, H., Hamoudi, R. A., Dupin, N., Meignin, V., Oksenhendler, E., Boshoff, C., Isaacson, P. G. (2001). Kaposi sarcoma-associated herpesvirus infects monotypic (IgM{lambda}) but polyclonal naive B cells in Castleman disease and associated lymphoproliferative disorders. Blood 97: 2130-2136 [Abstract] [Full Text]
Carbone, A., Gloghini, A., Larocca, L. M., Capello, D., Pierconti, F., Canzonieri, V., Tirelli, U., Dalla-Favera, R., Gaidano, G. (2001). Expression profile of MUM1/IRF4, BCL-6, and CD138/syndecan-1 defines novel histogenetic subsets of human immunodeficiency virus-related lymphomas. Blood 97: 744-751 [Abstract] [Full Text]
Stein, H., Marafioti, T., Foss, H.-D., Laumen, H., Hummel, M., Anagnostopoulos, I., Wirth, T., Demel, G., Falini, B. (2001). Down-regulation of BOB.1/OBF.1 and Oct2 in classical Hodgkin disease but not in lymphocyte predominant Hodgkin disease correlates with immunoglobulin transcription. Blood 97: 496-501 [Abstract] [Full Text]
Rai, K. R., Dohner, H., Keating, M. J., Montserrat, E. (2001). Chronic Lymphocytic Leukemia: Case-Based Session. ASH Education Book 2001: 140-156 [Abstract] [Full Text]
Harris, N. L., Stein, H., Coupland, S. E., Hummel, M., Favera, R. D., Pasqualucci, L., Chan, W. C. (2001). New Approaches to Lymphoma Diagnosis. ASH Education Book 2001: 194-220 [Abstract] [Full Text]
Ciric, B., VanKeulen, V., Rodriguez, M., Kyle, R. A., Gertz, M. A., Pease, L. R. (2001). Clonal evolution in Waldenstrom macroglobulinemia highlights functional role of B-cell receptor. Blood 97: 321-323 [Abstract] [Full Text]
Muschen, M., Re, D., Jungnickel, B., Diehl, V., Rajewsky, K., Kuppers, R. (2000). Somatic Mutation of the CD95 Gene in Human B Cells as a Side-Effect of the Germinal Center Reaction. JEM 192: 1833-1840 [Abstract] [Full Text]
Aguiar, R. C. T., Yakushijin, Y., Kharbanda, S., Salgia, R., Fletcher, J. A., Shipp, M. A. (2000). BAL is a novel risk-related gene in diffuse large B-cell lymphomas that enhances cellular migration. Blood 96: 4328-4334 [Abstract] [Full Text]
Odendahl, M., Jacobi, A., Hansen, A., Feist, E., Hiepe, F., Burmester, G. R., Lipsky, P. E., Radbruch, A., Dorner, T. (2000). Disturbed Peripheral B Lymphocyte Homeostasis in Systemic Lupus Erythematosus. J. Immunol. 165: 5970-5979 [Abstract] [Full Text]
De Re, V., De Vita, S., Marzotto, A., Rupolo, M., Gloghini, A., Pivetta, B., Gasparotto, D., Carbone, A., Boiocchi, M. (2000). Sequence analysis of the immunoglobulin antigen receptor of hepatitis C virus-associated non-Hodgkin lymphomas suggests that the malignant cells are derived from the rheumatoid factor-producing cells that occur mainly in type II cryoglobulinemia. Blood 96: 3578-3584 [Abstract] [Full Text]
Attaelmannan, M., Levinson, S. S. (2000). Understanding and Identifying Monoclonal Gammopathies. Clin. Chem. 46: 1230-1238 [Abstract] [Full Text]
Willenbrock, K., Roers, A., Blohbaum, B., Rajewsky, K., Hansmann, M.-L. (2000). CD8+ T Cells in Hodgkin's Disease Tumor Tissue Are a Polyclonal Population with Limited Clonal Expansion but Little Evidence of Selection by Antigen. Am. J. Pathol. 157: 171-175 [Abstract] [Full Text]
Narducci, M. G., Pescarmona, E., Lazzeri, C., Signoretti, S., Lavinia, A. M., Remotti, D., Scala, E., Baroni, C. D., Stoppacciaro, A., Croce, C. M., Russo, G. (2000). Regulation of TCL1 Expression in B- and T-Cell Lymphomas and Reactive Lymphoid Tissues. Cancer Res. 60: 2095-2100 [Abstract] [Full Text]
Macintyre, E., Willerford, D., Morris, S. W. (2000). Non-Hodgkin's Lymphoma: Molecular Features of B Cell Lymphoma. ASH Education Book 2000: 180-204 [Abstract] [Full Text]

Comments and questions? Please contact us.