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Previous Volume 341:1543-1544 November 11, 1999 Number 20 Next

	Since this article has no abstract, we have provided an extract of the first 100 words of the full text and any section headings.

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The development of effective treatments for stroke has focused on two general strategies. The first, thrombolysis, became available in 1996, when the Food and Drug Administration approved alteplase (tissue plasminogen activator) for administration within three hours after the onset of ischemic stroke. The goal of thrombolysis is to restore blood flow by lysing an intraarterial thrombus before brain cells die. The second, neuroprotection, is still in the preclinical pipeline. Its aim is to attenuate the intrinsic vulnerability of brain tissue to ischemia by blocking biochemical cascades that cause secondary injury. Prominent among these cascades is the neurotoxicity induced by the . . . [Full Text of this Article]

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