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Correspondence
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Volume 341:1546-1548 November 11, 1999 Number 20
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Fluoroquinolone Resistance in Streptococcus pneumoniae

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 by Chen, D. K.
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To the Editor: Chen et al. (July 22 issue)1 report an increasing prevalence of Streptococcus pneumoniae strains with reduced susceptibility to fluoroquinolones in Canada. We have found similar results in Barcelona, Spain.

Of 2822 pneumococcal isolates studied in our institution from 1991 through 1998, 57 (2.0 percent) were resistant to ciprofloxacin (minimal inhibitory concentration, >=4 µg per milliliter). We have seen an increase of ciprofloxacin-resistant pneumococci, from 0.9 percent (6 of 675 strains) in 1991–1992 to 3.0 percent (22 of 727 strains) in 1997–1998 (P=0.004). The use of fluoroquinolones in Spain has also increased during the past 13 years, from . . . [Full Text of this Article]

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