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Previous Volume 341:1577-1581 November 18, 1999 Number 21 Next

	Since this article has no abstract, we have provided an extract of the first 100 words of the full text and any section headings.

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Corticotropin-independent Cushing's syndrome is usually caused by cortisol-secreting adrenal adenomas, carcinomas, or (rarely) bilateral adrenal hyperplasia. In some patients with this syndrome, the excess secretion of cortisol is caused by abnormal adrenal expression and function of receptors for various hormones, including gastric inhibitory polypeptide,^1,2,3,4,5,6 vasopressin,^7,8,9 ß-adrenergic agonists,¹⁰ and interleukin-1.¹¹ These findings suggest that diverse other hormone receptors could be implicated in other patients.¹²

We describe a woman with bilateral adrenal hyperplasia and corticotropin-independent Cushing's syndrome that was clinically manifested transiently during her pregnancies and became constant only after menopause. The patient's cortisol secretion was stimulated by luteinizing hormone and chorionic . . . [Full Text of this Article]

Case Report

Methods

Clinical Studies

Assays

Results

Discussion

Source Information

From the Division of Endocrinology, Department of Medicine, Research Center, Hôtel-Dieu du Centre Hospitalier de l'Université de Montréal, Montreal.

Address reprint requests to Dr. Lacroix at the Research Center, Hôtel-Dieu du CHUM, 3850 St.-Urbain, Montreal, QC H2W 1T8, Canada, or at andre.lacroix@umontreal.ca.

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