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Previous Volume 341:1622-1623 November 18, 1999 Number 21 Next

	Since this article has no abstract, we have provided an extract of the first 100 words of the full text and any section headings.

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To the Editor: Ponec et al. (July 15 issue)¹ reported that treatment with neostigmine rapidly decompresses the colon in patients with acute colonic pseudo-obstruction who have not had a response to conservative therapy. Symptomatic bradycardia, however, developed in two patients.

Because bradycardia is a well-recognized and important complication of neostigmine therapy, use of neostigmine for reversal of neuromuscular blockade in the operating room is always accompanied by administration of an antimuscarinic anticholinergic agent such as atropine or glycopyrrolate. Although the authors recognized that administration of glycopyrrolate has not been shown to decrease colonic motility, they did not administer it prophylactically. . . . [Full Text of this Article]

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