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Previous Volume 341:1623-1624 November 18, 1999 Number 21 Next

	Since this article has no abstract, we have provided an extract of the first 100 words of the full text and any section headings.

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To the Editor: Indeed, vaccines are among the triumphs of medical science. However, the enthusiasm of Seder and Gurunathan (July 22 issue)¹ must be tempered with prudent restraint. They understate the potential harm to the patient evoked by "a strong cellular immune response not only against the microbial antigen but also against the host's own antigens." Producing immunity by genetically engineered vaccines should not involve a risk of producing disease by immunostimulatory nucleotide sequences contained in plasmid vectors.

Peter C. Freis, M.D.
Robert Wood Johnson University Hospital
New Brunswick, NJ 08901

References

1. Seder RA, Gurunathan S. DNA vaccines -- designer vaccines for the 21st century. N Engl J Med 1999;341:277-278. [Free Full Text]

To the Editor: We appreciate the . . . [Full Text of this Article]

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