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Previous Volume 341:1624-1626 November 18, 1999 Number 21 Next

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To the Editor: Women who have infertility due to anovulation in association with the polycystic ovary syndrome are particularly difficult to treat. A substantial proportion have no response to the induction of ovulation, and those who do have a response are at increased risk for the ovarian hyperstimulation syndrome. This syndrome is characterized by massive ovarian enlargement, ascites, pleural effusion, oliguria, hydrothorax, hemoconcentration, electrolyte disturbances, and in the most severe cases, thromboembolic phenomena related to coagulation disturbances. A woman with the polycystic ovary syndrome who became pregnant after in vitro maturation of oocytes and in vitro fertilization was described in . . . [Full Text of this Article]

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