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Correspondence
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Volume 341:1698-1700 November 25, 1999 Number 22
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Maternal Viral Load and the Risk of Perinatal Transmission of HIV-1

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 by Mofenson, L. M.
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To the Editor: In the August 5 issue, Mofenson et al.1 conclude that antiretroviral therapy "should be recommended to all infected pregnant women regardless of their HIV-1 [human immunodeficiency virus type 1] RNA levels," and Garcia et al.2 conclude that zidovudine therapy has "demonstrated efficacy in reducing the risk of transmission regardless of the maternal HIV-1 RNA levels." Neither study provides sufficient evidence to support these statements.

We updated the results of a meta-analysis of the predictive value of viral load for perinatal HIV-1 transmission3 with data presented by Garcia et al. Among 10 studies of pregnant women in the . . . [Full Text of this Article]

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