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Previous Volume 341:1701 November 25, 1999 Number 22 Next

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To the Editor: Brisinda et al. (July 8 issue)¹ report that healing of chronic anal fissure occurred in 22 of the 25 patients in the group receiving botulinum-toxin injections and in 10 of the 25 patients treated with topical nitroglycerin ointment. In addition, symptomatic improvement, defined by the authors as the absence of symptoms despite the persistence of the fissure, occurred in 2 of the 3 remaining patients in the botulinum-toxin group and 8 of the remaining 15 patients in the nitroglycerin group. These results indicate that healing of fissure and resolution of symptoms should not be equated. The authors . . . [Full Text of this Article]

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