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Previous Volume 341:1817-1828 December 9, 1999 Number 24 Next

	Since this article has no abstract, we have provided an extract of the first 100 words of the full text and any section headings.

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Skin is the primary interface between the body and the environment. The spectrum of insults to which skin is susceptible includes disorders caused by chemical and microbial agents, thermal and electromagnetic radiation, and mechanical trauma. The most damaging consequence of the disruption of skin is invasion by pathogenic microorganisms, and the need for an effective means of protection against this challenge has been a fundamental force behind the evolution of the immune system. The translation of insults into cutaneous inflammation (innate immunity) and the recruitment of memory T lymphocytes that have clonally expanded in response to antigens encountered at the . . . [Full Text of this Article]

T Cells and Immune Surveillance

Cutaneous Inflammation, Cytokines, and Nuclear Factor-b–Mediated Pathways

CLA-Positive T Cells and Cutaneous Inflammation

T-Cell–Mediated Skin Diseases

Psoriasis

Allergic Contact Dermatitis

Atopic Dermatitis

Cutaneous Graft-Versus-Host Disease

Cutaneous T-Cell Lymphoma

Conclusions

Source Information

From the Harvard Skin Disease Research Center, Harvard University; and the Division of Dermatology, Department of Medicine, Brigham and Women's Hospital — both in Boston.

Address reprint requests to Dr. Kupper at the Harvard Skin Disease Research Center, Harvard Institutes of Medicine, 77 Ave. Louis Pasteur, Boston, MA 02115, or at tskupper@rics.bwh.harvard.edu.

References

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