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Previous Volume 341:1837-1838 December 9, 1999 Number 24 Next

	Since this article has no abstract, we have provided an extract of the first 100 words of the full text and any section headings.

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The dependence of the growth of prostate cancer on androgens is well documented. Androgen ablation triggers a cascade of biologic events that ends in irreversible damage to the DNA of androgen-sensitive prostate-cancer cells.¹ Such treatment, traditionally reserved for men with metastatic disease, results in major objective and subjective benefits in most patients. However, in approximately 50 percent of patients, disease progression occurs 12 to 18 months after the initiation of treatment, and as a result, survival rates have not increased over the past five decades.² Androgen ablation controls the tumor only temporarily because prostate cancer consists of androgen-dependent and androgen-independent . . . [Full Text of this Article]

References

Related Letters:

Early Hormonal Therapy in Prostate Cancer
Swanson G. P., Messing E. M., Manola J.
Extract | Full Text  
N Engl J Med 2000; 342:1215-1216, Apr 20, 2000. Correspondence

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