FREE NEJM E-TOC    HOME   |   SUBSCRIBE   |   CURRENT ISSUE   |   PAST ISSUES   |   COLLECTIONS   |   Search Term  Advanced Search

Sign in | Get NEJM's E-Mail Table of Contents — Free | Subscribe

Previous Volume 341:1855-1856 December 9, 1999 Number 24 Next

	Since this article has no abstract, we have provided an extract of the first 100 words of the full text and any section headings.

	Full Text Purchase this article Add to Personal Archive Add to Citation Manager Notify a Friend E-mail When Cited PubMed Citation

To the Editor: Familial hypertrophic cardiomyopathy is a heterogeneous disease caused by mutations in eight different genes that encode cardiac sarcomeric proteins. Relatives of affected persons are at low risk for the disease in later life if the electrocardiographic and two-dimensional echocardiographic findings are normal in early adulthood. The only reported exceptions are patients with mutations in the gene for cardiac myosin-binding protein C, in whom the disease typically develops in middle age.^1,2 We describe a 57-year-old man with hypertrophic cardiomyopathy caused by a mutation in the gene for troponin T.

The patient presented with a three-year history of exertional . . . [Full Text of this Article]

References

This article has been cited by other articles:

• Sirenko, S. G., Potter, J. D., Knollmann, B. C. (2006). Differential effect of troponin T mutations on the inotropic responsiveness of mouse hearts - role of myofilament Ca2+ sensitivity increase. J. Physiol. 575: 201-213 [Abstract] [Full Text]  
• Hernandez, O. M., Szczesna-Cordary, D., Knollmann, B. C., Miller, T., Bell, M., Zhao, J., Sirenko, S. G., Diaz, Z., Guzman, G., Xu, Y., Wang, Y., Kerrick, W. G. L., Potter, J. D. (2005). F110I and R278C Troponin T Mutations That Cause Familial Hypertrophic Cardiomyopathy Affect Muscle Contraction in Transgenic Mice and Reconstituted Human Cardiac Fibers. J. Biol. Chem. 280: 37183-37194 [Abstract] [Full Text]  
• Miliou, A, Anastasakis, A, D'Cruz, L G, Theopistou, A, Rigopoulos, A, Rizos, I, Stamatelopoulos, S, Toutouzas, P, Stefanadis, C (2005). Low prevalence of cardiac troponin T mutations in a Greek hypertrophic cardiomyopathy cohort. Heart 91: 966-967 [Full Text]  
• Hernandez, O. M., Housmans, P. R., Potter, J. D. (2001). Plasticity in Skeletal, Cardiac, and Smooth Muscle: Invited Review: Pathophysiology of cardiac muscle contraction and relaxation as a result of alterations in thin filament regulation. J. Appl. Physiol. 90: 1125-1136 [Abstract] [Full Text]