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Previous Volume 341:1856-1857 December 9, 1999 Number 24 Next

	Since this article has no abstract, we have provided an extract of the first 100 words of the full text and any section headings.

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To the Editor: Otto et al. (July 15 issue)¹ reported that the presence of aortic-valve disease without stenosis was associated with an increased risk of death from any cause and death from cardiovascular causes among the participants in the Cardiovascular Health Study and its supplemental cohort. One plausible explanation for this finding is inadequate adjustment for confounding variables. In fact, the authors did not adjust for the presence of renal insufficiency or impaired functional capacity — two variables that differed significantly between subjects with and those without aortic sclerosis.

Furthermore, a multivariate analysis from the same study group² (which excluded . . . [Full Text of this Article]

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