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Previous Volume 341:1938 December 16, 1999 Number 25 Next

	Since this article has no abstract, we have provided an extract of the first 100 words of the full text and any section headings.

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To the Editor: Experimental studies suggest that metabolic acidosis impairs the contractile function of the heart, but whether this occurs in humans is uncertain.^1,2 During a six-month period, we measured fractional shortening of the left ventricle during systole in 10 consecutive patients (6 women and 4 men; mean [±SD] age, 42±18 years), 7 of whom were admitted for treatment of diabetic ketoacidosis and 3 of whom were admitted for alcoholic ketoacidosis. We focused on these conditions because the ketoacidosis associated with them, although frequently severe, is usually rapidly reversible.

Treatment included intravenous rehydration (mean volume of fluid infused, 3.1±1.6 liters), . . . [Full Text of this Article]

References

This article has been cited by other articles:

• Handy, J. M., Soni, N. (2008). Physiological effects of hyperchloraemia and acidosis. Br J Anaesth 101: 141-150 [Abstract] [Full Text]  
• Rosival, V. (2006). Treating metabolic acidosis.. QJM 99: 881-881 [Full Text]  
• Fall, P. J., Szerlip, H. M. (2005). Lactic Acidosis: From Sour Milk to Septic Shock. J Intensive Care Med 20: 255-271 [Abstract]