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Previous Volume 341:342-352 July 29, 1999 Number 5 Next

	Since this article has no abstract, we have provided an extract of the first 100 words of the full text and any section headings.

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Common malignant tumors of the musculoskeletal system in children, adolescents, and young adults (<30 years old) include rhabdomyosarcoma, osteosarcoma, and Ewing's sarcoma. Together they constitute about 10 percent of newly diagnosed cancers in children, adolescents, and young adults (about 1000 cases annually in the United States). Although relatively common in young persons, these tumors are rare in older people.

Rhabdomyosarcomas constitute more than half of all soft-tissue sarcomas in children.¹ Other soft-tissue sarcomas are highly heterogeneous and individually rare (e.g., synovial sarcoma and sarcomas of soft parts); thus, they are not discussed further. Osteosarcoma comprises several high-grade histologic variants and . . . [Full Text of this Article]

Epidemiology

Clinical Features

Diagnosis and Staging

Morphologic and Immunohistochemical Features

Genetic Features

Rhabdomyosarcoma

Osteosarcoma

Ewing's Sarcoma

Treatment

Principles of Therapy

Rhabdomyosarcoma

Osteosarcoma

Ewing's Sarcoma

Treatment of Relapse

Future Directions

Source Information

From the Department of Pediatric and Adolescent Medicine, Mayo Clinic, Mayo Foundation, and Mayo Medical School, Rochester, Minn.

Address reprint requests to Dr. Arndt at the Department of Pediatric and Adolescent Medicine, Mayo Clinic, 200 First St. SW, Rochester, MN 55905, or at arndt.carola@mayo.edu.

References

Related Letters:

Musculoskeletal Tumors of Childhood
Mehta P., Wingard J. R., Arndt C. A.S., Crist W. M.
Extract | Full Text  
N Engl J Med 1999; 341:1701-1702, Nov 25, 1999. Correspondence

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